The effect of systematic structural modifications on the antibacterial activity of novel oxazolidinones

Gábor Pintér, Ilona Bereczki, Elizabeth Roth, Attila Sipos, Reny Varghese, Edet Ekpenyong Udo, Eszter Ostorházi, Ferenc Rozgonyi, Oludotun Adebayo Phillips, Pál Herczegh

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A novel series of tetraethylene glycol (TEG) triazolyl and squaramide containing oxazolidinones were synthesized and tested for their antibacterial activity against a selected panel of Gram-positive and Gram-negative bacteria. The 4-TEG-triazolyl derivatives were prepared by 'click reaction'. The introduction of the TEG and squaramide groups did not favor antibacterial activity. The three nucleoside-containing oxazolidinones were also prepared by 'click' methodology resulted in weak antibacterial activity.

Original languageEnglish
Pages (from-to)45-55
Number of pages11
JournalMedicinal Chemistry
Volume7
Issue number1
DOIs
Publication statusPublished - Jan 1 2011

Keywords

  • 'Click' reaction
  • Antibacterial agents
  • Linezolid
  • Oxazolidinone
  • Squaramide
  • Tetraethylene glycol (TEG)

ASJC Scopus subject areas

  • Drug Discovery

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  • Cite this

    Pintér, G., Bereczki, I., Roth, E., Sipos, A., Varghese, R., Udo, E. E., Ostorházi, E., Rozgonyi, F., Phillips, O. A., & Herczegh, P. (2011). The effect of systematic structural modifications on the antibacterial activity of novel oxazolidinones. Medicinal Chemistry, 7(1), 45-55. https://doi.org/10.2174/157340611794072670