The effect of storage on the behaviour of Eudragit NE free film

J. Bajdik, K. Pintye-Hódi, G. Regdon, P. Fazekas, P. Szabó-Révész, I. Erös

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Eudragit NE 30 D aqueous dispersion is a commonly used coating material, which contains methacrylate copolymers as film-forming agent and nonoxynol 100 as an endogenous emulsifier. The dissolution of the active ingredient from Eudragit NE-coated samples during storage is known to undergo a change. The crystallization of the emulsifier agent can play an important role in this. This polymer is not soluble in the gastrointestinal tract, but is permeable. Various parameters can influence the permeability of this film, e.g. via the tensile properties of the film. Change in the film thickness can cause the stretching of the film on a solid surface. Alterations in this physical parameter of the film were measured and the effects of different storage conditions were evaluated. The free film was prepared by spraying onto teflon. The crystallization of nonoxynol was followed via the changes in the DSC curve of the free film. A relationship was found between the film thickness and the crystallization of nonoxynol. It was established that the different storage conditions influence these changes. The temperature and the air humidity are important in this phenomenon. Lengthening of the storage time increased the difference in film thickness and crystallisation of emulsifier.

Original languageEnglish
Pages (from-to)607-613
Number of pages7
JournalJournal of Thermal Analysis and Calorimetry
Volume73
Issue number2
DOIs
Publication statusPublished - 2003

Fingerprint

Nonoxynol
Crystallization
crystallization
Film thickness
film thickness
Methacrylates
tensile properties
teflon (trademark)
spraying
Polytetrafluoroethylene
Spraying
methylmethacrylate-methacrylic acid copolymer
Tensile properties
Polytetrafluoroethylenes
ingredients
solid surfaces
Stretching
humidity
Atmospheric humidity
copolymers

Keywords

  • Crystallisation
  • Eudragit NE 30 D
  • Film thickness
  • Nonoxynol 100
  • Storage

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

The effect of storage on the behaviour of Eudragit NE free film. / Bajdik, J.; Pintye-Hódi, K.; Regdon, G.; Fazekas, P.; Szabó-Révész, P.; Erös, I.

In: Journal of Thermal Analysis and Calorimetry, Vol. 73, No. 2, 2003, p. 607-613.

Research output: Contribution to journalArticle

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