The effect of storage and active ingredient properties on the drug release profile of poly(ethylene oxide) matrix tablets

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Different molecular weight forms of poly(ethylene oxide) can be used successfully in controlled release drug delivery due to their excellent matrix forming properties. Drug release of these materials follows nearly zero order kinetics, and is mainly governed by polymer swelling and erosion and diffusion of drug molecules. Because of its partly amorphous structure, poly(ethylene oxide) undergoes structural changes caused by elevated temperature and relative humidity of the storage medium resulting in an increased drug release. This physical process can be highly influenced by the structure of different drug molecules, such as polymer-binding ability and hydration tendency. These properties of two basic drugs embedded into poly(ethylene oxide) matrices were characterized by molecular modelling and an attempt was made to reveal their effect on the change of drug release stability, a prerequisite of the marketing authorization of dosage forms. The findings suggest that both the hydration properties of the active ingredient and the molecular weight of the polymer influence the effect of physical ageing of poly(ethylene oxide) on the drug release properties of the matrix.

Original languageEnglish
Pages (from-to)930-933
Number of pages4
JournalCarbohydrate Polymers
Volume74
Issue number4
DOIs
Publication statusPublished - Nov 21 2008

Keywords

  • Ab initio calculations
  • Metronidazole
  • Physical ageing
  • Poly(ethylene oxide)
  • Theophylline

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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