The effect of somatostatin on self-stimulation behavior in atropine- and methysergide-pretreated rats

L. Vécsei, Helmut Schwarzberg, G. Telegdy

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The effect of somatostatin on lateral hypothalamic self-stimulation was investigated in atropine- and methysergide-pretreated rats. Somatostatin markedly decreased the self-stimulation rate of the animals. Atropine in a dose which had no action on self-stimulation partly antagonized the effect of somatostatin. Methysergide potentiated the somatostatin-induced depression of self-stimulation behavior. These results suggest that the central cholinergic and serotoninergic systems may play a role in the somatostatin-induced inhibition of self-stimulation.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalEuropean Journal of Pharmacology
Volume91
Issue number1
DOIs
Publication statusPublished - Jul 15 1983

Fingerprint

Self Stimulation
Methysergide
Somatostatin
Atropine
Cholinergic Agents

Keywords

  • Atropine
  • Methysergide
  • Self-stimulation
  • Somatostatin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

The effect of somatostatin on self-stimulation behavior in atropine- and methysergide-pretreated rats. / Vécsei, L.; Schwarzberg, Helmut; Telegdy, G.

In: European Journal of Pharmacology, Vol. 91, No. 1, 15.07.1983, p. 89-93.

Research output: Contribution to journalArticle

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