The effect of somatostatin on self-stimulation behavior in atropine- and methysergide-pretreated rats

Lászlo Vécsei, Helmut Schwarzberg, Gyula Telegdy

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The effect of somatostatin on lateral hypothalamic self-stimulation was investigated in atropine- and methysergide-pretreated rats. Somatostatin markedly decreased the self-stimulation rate of the animals. Atropine in a dose which had no action on self-stimulation partly antagonized the effect of somatostatin. Methysergide potentiated the somatostatin-induced depression of self-stimulation behavior. These results suggest that the central cholinergic and serotoninergic systems may play a role in the somatostatin-induced inhibition of self-stimulation.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalEuropean Journal of Pharmacology
Volume91
Issue number1
DOIs
Publication statusPublished - Jul 15 1983

Keywords

  • Atropine
  • Methysergide
  • Self-stimulation
  • Somatostatin

ASJC Scopus subject areas

  • Pharmacology

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