The effect of solid/liquid interactions on the migration of riboflavin in tray-dried granule beds

R. Zelkó, Z. Budavári, S. Marton, I. Rácz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The aim of the present study was to investigate how the content uniformity of tray-dried lactose granulates, containing water-insoluble drug (riboflavin), was influenced by the changes in the solid/liquid interactions. Riboflavin granules (0.01% w/w) were prepared with aqueous Kollidon 90 solutions of different concentrations. The riboflavin distribution in the tray-dried granulates was determined spectrophotometrically. To evaluate the solid/liquid interactions, different physicochemical methods measurement of apparent viscosity, dynamic surface tension, advancing and receding contact angle were applied. It can be concluded that the increased viscosity of the granulation liquid along with its decreased wetting capacity resulted in a more homogeneous drug distribution in the dried granulates.

Original languageEnglish
Pages (from-to)215-217
Number of pages3
JournalS.T.P. Pharma Sciences
Volume9
Issue number2
Publication statusPublished - Mar 1999

Fingerprint

Riboflavin
Viscosity
Povidone
Surface Tension
Lactose
Pharmaceutical Preparations
Water

Keywords

  • Advancing and receding contact angles
  • Apparent viscosity
  • Drug content of granules
  • Dynamic surface tension
  • Wetting capacity

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

The effect of solid/liquid interactions on the migration of riboflavin in tray-dried granule beds. / Zelkó, R.; Budavári, Z.; Marton, S.; Rácz, I.

In: S.T.P. Pharma Sciences, Vol. 9, No. 2, 03.1999, p. 215-217.

Research output: Contribution to journalArticle

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