The effect of serum triglyceride concentration on the outcome of acute pancreatitis

systematic review and meta-analysis

Lóránd Kiss, Gabriella Fűr, Péter Mátrai, P. Hegyi, Emese Ivány, Irina Mihaela Cazacu, Imre Szabó, Tamás Habon, Hussain Alizadeh, Zoltán Gyöngyi, Éva Vigh, Bálint Erőss, Adrienn Erős, Máté Ottoffy, L. Czakó, Z. Rakonczay

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Elevated serum triglyceride concentration (seTG, >1.7 mM or >150 mg/dL) or in other words hypertriglyceridemia (HTG) is common in the populations of developed countries. This condition is accompanied by an increased risk for various diseases, such as acute pancreatitis (AP). It has been proposed that HTG could also worsen the course of AP. Therefore, in this meta-analysis, we aimed to compare the effects of various seTGs on the severity, mortality, local and systemic complications of AP, and on intensive care unit admission. 16 eligible studies, including 11,965 patients were retrieved from PubMed and Embase. The results showed that HTG significantly elevated the odds ratio (OR = 1.72) for severe AP when compared to patients with normal seTG (<1.7 mM). Furthermore, a significantly higher occurrence of pancreatic necrosis, persistent organ failure and renal failure was observed in groups with HTG. The rates of complications and mortality for AP were significantly increased in patients with seTG >5.6 mM or >11.3 mM versus <5.6 mM or <11.3 mM, respectively. We conclude that the presence of HTG worsens the course and outcome of AP, but we found no significant difference in AP severity based on the extent of HTG.

Original languageEnglish
Article number14096
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - Dec 1 2018

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Hypertriglyceridemia
Pancreatitis
Meta-Analysis
Triglycerides
Serum
Developed Countries
PubMed
Intensive Care Units
Odds Ratio
Mortality
Population

ASJC Scopus subject areas

  • General

Cite this

The effect of serum triglyceride concentration on the outcome of acute pancreatitis : systematic review and meta-analysis. / Kiss, Lóránd; Fűr, Gabriella; Mátrai, Péter; Hegyi, P.; Ivány, Emese; Cazacu, Irina Mihaela; Szabó, Imre; Habon, Tamás; Alizadeh, Hussain; Gyöngyi, Zoltán; Vigh, Éva; Erőss, Bálint; Erős, Adrienn; Ottoffy, Máté; Czakó, L.; Rakonczay, Z.

In: Scientific Reports, Vol. 8, No. 1, 14096, 01.12.2018.

Research output: Contribution to journalArticle

Kiss, L, Fűr, G, Mátrai, P, Hegyi, P, Ivány, E, Cazacu, IM, Szabó, I, Habon, T, Alizadeh, H, Gyöngyi, Z, Vigh, É, Erőss, B, Erős, A, Ottoffy, M, Czakó, L & Rakonczay, Z 2018, 'The effect of serum triglyceride concentration on the outcome of acute pancreatitis: systematic review and meta-analysis', Scientific Reports, vol. 8, no. 1, 14096. https://doi.org/10.1038/s41598-018-32337-x
Kiss, Lóránd ; Fűr, Gabriella ; Mátrai, Péter ; Hegyi, P. ; Ivány, Emese ; Cazacu, Irina Mihaela ; Szabó, Imre ; Habon, Tamás ; Alizadeh, Hussain ; Gyöngyi, Zoltán ; Vigh, Éva ; Erőss, Bálint ; Erős, Adrienn ; Ottoffy, Máté ; Czakó, L. ; Rakonczay, Z. / The effect of serum triglyceride concentration on the outcome of acute pancreatitis : systematic review and meta-analysis. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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