The effect of sample storage on the reliability of thyroglobulin and thyroglobulin-antibody measurements

Zoltán Locsei, Erzsébet Toldy, I. Szabolcs, K. Rácz, G. Kovács

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives: To investigate how sample-storage alters thyroglobulin (Tg) and thyroglobulin-antibody (TgAb) immunoreactivity. Design and methods: Tg and TgAb measurements at different storage-times and -temperatures. Results: 48-h-storage at 4-10 °C (but not 8 h at room temperature) increased Tg and decreased TgAb immunoreactivity by maximum + 23% and - 16%. 4-weeks-storage at - 17 to - 20 °C decreased both Tg and TgAb by max. 21-31%. Conclusions: Storage of samples at 4-10 °C for > 24-48 h, or at - 17 to - 20 °C for > 2-3 weeks significantly alters Tg and TgAb immunoreactivity.

Original languageEnglish
Pages (from-to)225-228
Number of pages4
JournalClinical Biochemistry
Volume42
Issue number3
DOIs
Publication statusPublished - Feb 2009

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Thyroglobulin
Antibodies
Temperature

Keywords

  • Change of immunoreactivity
  • Sample storage
  • Thyroglobulin
  • Thyroglobulin-antibody

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

The effect of sample storage on the reliability of thyroglobulin and thyroglobulin-antibody measurements. / Locsei, Zoltán; Toldy, Erzsébet; Szabolcs, I.; Rácz, K.; Kovács, G.

In: Clinical Biochemistry, Vol. 42, No. 3, 02.2009, p. 225-228.

Research output: Contribution to journalArticle

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AU - Kovács, G.

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