The effect of ring size of fused chelates on the stability constants and spectroscopic properties of nickel(II) and palladium(II) complexes of peptides

Csaba Gábor Ágoston, Z. Miskolczy, Zoltán Nagy, I. Sóvágó

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Nickel(II) and palladium(II) complexes of di- and tri-peptides containing β-alanyl residues have been studied by potentiometric, UV-Vis and NMR spectroscopic methods. Coordination geometries of the metal ions were not affected by the chelate ring size, but the thermodynamic stability of the complexes was significantly influenced by the number and location of β-alanyl residues. The destabilizing effect of the N-terminal β-alanyl moieties was observed in all cases. The stability order for the (NH2, N-, N-, COO-) coordination mode of [NiH-2L]- complexes is described as follows: GlyGly-β-Ala (5,5,6) ≥ Gly-β-AlaGly (5,6,5) ≥ GlyGlyGly (5,5,5) > β-AlaGlyGly (6,5,5) > Gly-β-Ala-β-Ala (5,6,6) > β-AlaGly-β-Ala (6,5,6), while for the corresponding palladium(II) complexes: Gly-β-AlaGly (5,6,5) > GlyGly-β-Ala (5,5,6) > Gly-β-Ala-β-Ala (5,6,6) > GlyGlyGly (5,5,5) > β-AlaGly-β-Ala (6,5,6) ≥ β-AlaGlyGly (6,5,5). The data suggest that the inclusion of β-alanine into the internal or C-terminal positions of tripeptide molecules significantly enhances the metal binding ability of the ligands.

Original languageEnglish
Pages (from-to)2607-2615
Number of pages9
JournalPolyhedron
Volume22
Issue number18
DOIs
Publication statusPublished - Aug 1 2003

Fingerprint

Palladium
Nickel
chelates
Peptides
peptides
palladium
Metals
nickel
rings
alanine
Thermodynamics
Alanine
Metal ions
metal ions
Thermodynamic stability
Ligands
Nuclear magnetic resonance
inclusions
Ions
thermodynamics

Keywords

  • β-Alanine
  • Dipeptides
  • Nickel(II)
  • Palladium(II)
  • Stability constants
  • Tripeptides

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

The effect of ring size of fused chelates on the stability constants and spectroscopic properties of nickel(II) and palladium(II) complexes of peptides. / Gábor Ágoston, Csaba; Miskolczy, Z.; Nagy, Zoltán; Sóvágó, I.

In: Polyhedron, Vol. 22, No. 18, 01.08.2003, p. 2607-2615.

Research output: Contribution to journalArticle

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abstract = "Nickel(II) and palladium(II) complexes of di- and tri-peptides containing β-alanyl residues have been studied by potentiometric, UV-Vis and NMR spectroscopic methods. Coordination geometries of the metal ions were not affected by the chelate ring size, but the thermodynamic stability of the complexes was significantly influenced by the number and location of β-alanyl residues. The destabilizing effect of the N-terminal β-alanyl moieties was observed in all cases. The stability order for the (NH2, N-, N-, COO-) coordination mode of [NiH-2L]- complexes is described as follows: GlyGly-β-Ala (5,5,6) ≥ Gly-β-AlaGly (5,6,5) ≥ GlyGlyGly (5,5,5) > β-AlaGlyGly (6,5,5) > Gly-β-Ala-β-Ala (5,6,6) > β-AlaGly-β-Ala (6,5,6), while for the corresponding palladium(II) complexes: Gly-β-AlaGly (5,6,5) > GlyGly-β-Ala (5,5,6) > Gly-β-Ala-β-Ala (5,6,6) > GlyGlyGly (5,5,5) > β-AlaGly-β-Ala (6,5,6) ≥ β-AlaGlyGly (6,5,5). The data suggest that the inclusion of β-alanine into the internal or C-terminal positions of tripeptide molecules significantly enhances the metal binding ability of the ligands.",
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T1 - The effect of ring size of fused chelates on the stability constants and spectroscopic properties of nickel(II) and palladium(II) complexes of peptides

AU - Gábor Ágoston, Csaba

AU - Miskolczy, Z.

AU - Nagy, Zoltán

AU - Sóvágó, I.

PY - 2003/8/1

Y1 - 2003/8/1

N2 - Nickel(II) and palladium(II) complexes of di- and tri-peptides containing β-alanyl residues have been studied by potentiometric, UV-Vis and NMR spectroscopic methods. Coordination geometries of the metal ions were not affected by the chelate ring size, but the thermodynamic stability of the complexes was significantly influenced by the number and location of β-alanyl residues. The destabilizing effect of the N-terminal β-alanyl moieties was observed in all cases. The stability order for the (NH2, N-, N-, COO-) coordination mode of [NiH-2L]- complexes is described as follows: GlyGly-β-Ala (5,5,6) ≥ Gly-β-AlaGly (5,6,5) ≥ GlyGlyGly (5,5,5) > β-AlaGlyGly (6,5,5) > Gly-β-Ala-β-Ala (5,6,6) > β-AlaGly-β-Ala (6,5,6), while for the corresponding palladium(II) complexes: Gly-β-AlaGly (5,6,5) > GlyGly-β-Ala (5,5,6) > Gly-β-Ala-β-Ala (5,6,6) > GlyGlyGly (5,5,5) > β-AlaGly-β-Ala (6,5,6) ≥ β-AlaGlyGly (6,5,5). The data suggest that the inclusion of β-alanine into the internal or C-terminal positions of tripeptide molecules significantly enhances the metal binding ability of the ligands.

AB - Nickel(II) and palladium(II) complexes of di- and tri-peptides containing β-alanyl residues have been studied by potentiometric, UV-Vis and NMR spectroscopic methods. Coordination geometries of the metal ions were not affected by the chelate ring size, but the thermodynamic stability of the complexes was significantly influenced by the number and location of β-alanyl residues. The destabilizing effect of the N-terminal β-alanyl moieties was observed in all cases. The stability order for the (NH2, N-, N-, COO-) coordination mode of [NiH-2L]- complexes is described as follows: GlyGly-β-Ala (5,5,6) ≥ Gly-β-AlaGly (5,6,5) ≥ GlyGlyGly (5,5,5) > β-AlaGlyGly (6,5,5) > Gly-β-Ala-β-Ala (5,6,6) > β-AlaGly-β-Ala (6,5,6), while for the corresponding palladium(II) complexes: Gly-β-AlaGly (5,6,5) > GlyGly-β-Ala (5,5,6) > Gly-β-Ala-β-Ala (5,6,6) > GlyGlyGly (5,5,5) > β-AlaGly-β-Ala (6,5,6) ≥ β-AlaGlyGly (6,5,5). The data suggest that the inclusion of β-alanine into the internal or C-terminal positions of tripeptide molecules significantly enhances the metal binding ability of the ligands.

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