The effect of recombination on the neutral evolution of genetic robustness

Gergely J. Szöllosi, I. Derényi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Conventional population genetics considers the evolution of a limited number of genotypes corresponding to phenotypes with different fitness. As model phenotypes, in particular RNA secondary structure, have become computationally tractable, however, it has become apparent that the context dependent effect of mutations and the many-to-one nature inherent in these genotype-phenotype maps can have fundamental evolutionary consequences. It has previously been demonstrated that populations of genotypes evolving on the neutral networks corresponding to all genotypes with the same secondary structure only through neutral mutations can evolve mutational robustness [E. van Nimwegen, J.P. Crutchfield, M. Huynen, Neutral evolution of mutational robustness, Proc. Natl. Acad. Sci. USA 96(17), 9716-9720 (1999)], by concentrating the population on regions of high neutrality. Introducing recombination we demonstrate, through numerically calculating the stationary distribution of an infinite population on ensembles of random neutral networks that mutational robustness is significantly enhanced and further that the magnitude of this enhancement is sensitive to details of the neutral network topology. Through the simulation of finite populations of genotypes evolving on random neutral networks and a scaled down microRNA neutral network, we show that even in finite populations recombination will still act to focus the population on regions of locally high neutrality.

Original languageEnglish
Pages (from-to)58-62
Number of pages5
JournalMathematical Biosciences
Volume214
Issue number1-2
DOIs
Publication statusPublished - Jul 2008

Fingerprint

Neutral Networks
Genetic Drift
Genotype
RNA
MicroRNAs
Recombination
Genetic Recombination
recombination
genotype
Topology
Robustness
Phenotype
phenotype
Neutrality
secondary structure
Population
Finite Population
Random Networks
mutation
Mutation

Keywords

  • Mutational robustness
  • Neutral networks
  • Population dynamics
  • Recombination

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Ecology, Evolution, Behavior and Systematics

Cite this

The effect of recombination on the neutral evolution of genetic robustness. / Szöllosi, Gergely J.; Derényi, I.

In: Mathematical Biosciences, Vol. 214, No. 1-2, 07.2008, p. 58-62.

Research output: Contribution to journalArticle

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