In behavioral and biochemical studies V-III has been shown to influence the serotonergic system of the rat's brain selectively. It has been shown that a single dose of V-III (15 mg/kg sc) releases serotonin (5-HT) in the brain and causes disturbances in the behavioral performances of Wistar rats; a one month treatment (15 mg/kg daily) with V-III, however, results in a decrease in the 5-HT content of the brain and improves the performances of the animal in some behavioral tests. Evidence has been presented that different serotonergic drugs are able to stimulate the flexor reflex of spinal rat. The effect of musculus tibialis anterior to paw stimulation was studied in rats with spinal cord dissection. Acute V-III treatment (250-1000 μg/kg) potentiated the flexor reflex which was inhibited by mianserin. 24 hr after chronic V-III treatment (15 mg/kg sc daily for one month) a single dose of V-III became ineffective. The effect of V-III on flexor reflex was also inhibited by both p-chloroamphetamine (PCA) and by p-chlorophenylalanine (PCPA) pretreatment.
|Number of pages||7|
|Journal||Polish journal of pharmacology and pharmacy|
|Publication status||Published - Dec 1 1978|
ASJC Scopus subject areas
- Pharmaceutical Science