The effect of Pygeum Africanum on fibroblast growth factor (FGF) and transforming growth factor beta (TGFβ1/LAP) expression in animal model

Erzsébet Szolnoki, E. Reichart, Sophie Marchal, G. Szegedi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

On the basis of its fibroblast growth factor (FGF) inhibitory effect we assessed the possible inhibitory anti-inflammatory role of Pygeum Africanum extract (Tadenan) on FGF and transforming growth factor beta (TGFβ1/LAP) expression of macrophages and neutrophils in broncho-alveolar lavage fluid (BAL) of rats in a bleomycin-induced acute inflammation model. The rats were divided into three groups: 17 untreated controls, 10 bleomycin-instilled rats, receiving NaCl (0.9%), and 10 rats receiving Pygeum Africanum extract. On the 12th (and 15th day) we performed BAL and after labelling of cells expression of FGF and TGFβ1 (LAP) was measured by flow-cytometry. We made a quantitative analysis of BAL cells as well. One-way ANOVA was used for statistical analysis. We found in Pygeum Africanum extract treated group 1, a significantly decreased number of neutrophil granulocytes (p <0.05) compared with other groups 2, there was a considerable decrease (not significant) in expression of TGFβ1(LAP) on BAL macrophages, but not in case of FGF. In conclusion: our results show the possible 1. inhibitory effect of this drug on TGFβ1 (LAP) expression, 2. anti-inflammatory role on neutrophil granulocytes.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalActa Microbiologica et Immunologica Hungarica
Volume48
Issue number1
DOIs
Publication statusPublished - 2001

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Fibroblast Growth Factors
Bronchoalveolar Lavage Fluid
Transforming Growth Factor beta
Animal Models
Neutrophils
Granulocytes
Anti-Inflammatory Agents
Macrophages
Bleomycin
Analysis of Variance
Flow Cytometry
Inflammation
Prunus africana
Pharmaceutical Preparations

Keywords

  • Anti-inflammatory drug
  • Fibroblast growth factor
  • Transforming growth factor beta

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Medicine(all)
  • Microbiology

Cite this

The effect of Pygeum Africanum on fibroblast growth factor (FGF) and transforming growth factor beta (TGFβ1/LAP) expression in animal model. / Szolnoki, Erzsébet; Reichart, E.; Marchal, Sophie; Szegedi, G.

In: Acta Microbiologica et Immunologica Hungarica, Vol. 48, No. 1, 2001, p. 1-9.

Research output: Contribution to journalArticle

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