The effect of potassium canrenoate (Aldactone) on the norepinephrine metabolism and potassium ionic currents of the heart.

Z. Antalóczy, M. Sebeszta, I. Préda

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Abstract

Under experimental conditions, potassium canrenoate causes a significant increase in [3H]norepinephrine (NE) uptake by the heart, although the NE content remains unchanged. The increased NE uptake and unchanged NE content indicate an augmented NE turnover caused by the drug. In saluretic-pretreated animals, the intracellular hypopotassemia can be restored by Aldactone. This effect can be explained by the inhibition of the outward potassium current. When we simulated the pathophysiological conditions of the acute phase of myocardial infarction by using a K+-rich superfusate to partially depolarize the myocardial cells, slow action potentials were elicited by NE in isolated papillary muscles. Our microelectrode experiments revealed that Aldactone, by its blocking effect on the potassium conductance, increases the duration of the slow action potentials and decreases the threshold NE concentration required to elicit the slow responses. However, in clinical conditions with a higher level of circulating catecholamine and/or hyperpotassemia, the administration of the drug has a considerable risk of provoking arrhythmias.

Original languageEnglish
Pages (from-to)215-222
Number of pages8
JournalAdvances in myocardiology
Volume3
Publication statusPublished - 1982

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Canrenoic Acid
Spironolactone
Norepinephrine
Potassium
Action Potentials
Hyperkalemia
Hypokalemia
Papillary Muscles
Microelectrodes
Pharmaceutical Preparations
Catecholamines
Cardiac Arrhythmias
Myocardial Infarction

ASJC Scopus subject areas

  • Medicine(all)

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The effect of potassium canrenoate (Aldactone) on the norepinephrine metabolism and potassium ionic currents of the heart. / Antalóczy, Z.; Sebeszta, M.; Préda, I.

In: Advances in myocardiology, Vol. 3, 1982, p. 215-222.

Research output: Contribution to journalArticle

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