The effect of polyethylene glycol by gavage on electrolyte and water excretion in the rat

S. Sonkodi, B. Tichy, W. B. Brown, J. I S Robertson

Research output: Contribution to journalArticle

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Abstract

1. The effects of polyethylene glycol (PEG) 200 administered by gavage on electrolyte and water excretion were investigated in the rat. 2. PEG 200 led, in intact rats to dose-related increased drinking and to diuresis. 3. In the first 2 h after PEG 200 administration, water consumption in intact rats exceeded urine output. 4. PEG 200 enhanced the excretion of both sodium and potassium, but the sodium excretion was proportionately greater, resulting in an elevation of the urinary sodium/potassium ratio. 5. Bilateral nephrectomy was not accompanied by increased drinking in PEG 200-treated rats, although raised serum osmolality was seen. 6. Thus, given by gavage, PEG 200 is not an inert vehicle for drug administration.

Original languageEnglish
Pages (from-to)445-448
Number of pages4
JournalClinical Science
Volume71
Issue number4
Publication statusPublished - 1986

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Electrolytes
Water
Drinking
Sodium
Potassium
Diuresis
Nephrectomy
Osmolar Concentration
Urine
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The effect of polyethylene glycol by gavage on electrolyte and water excretion in the rat. / Sonkodi, S.; Tichy, B.; Brown, W. B.; Robertson, J. I S.

In: Clinical Science, Vol. 71, No. 4, 1986, p. 445-448.

Research output: Contribution to journalArticle

Sonkodi, S, Tichy, B, Brown, WB & Robertson, JIS 1986, 'The effect of polyethylene glycol by gavage on electrolyte and water excretion in the rat', Clinical Science, vol. 71, no. 4, pp. 445-448.
Sonkodi, S. ; Tichy, B. ; Brown, W. B. ; Robertson, J. I S. / The effect of polyethylene glycol by gavage on electrolyte and water excretion in the rat. In: Clinical Science. 1986 ; Vol. 71, No. 4. pp. 445-448.
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