The effect of polycythemia and hypoxia on urinary N-acetyl-β-D-glucosaminidase activity in newborns

László Csáthy, I. Pócsi, L. Kiss, G. Balla, Neena Modi, Robert G. Price

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Urinary N-acetyl-β-D-glucosaminidase activity was assayed in fullterm and preterm polycythemic neonates, in preterm infants with hypoxia, and in healthy newborns. There were no significant differences between fullterm and preterm babies or between appropriate for gestational age and small for gestational age neonates in the normal group. N-acetyl-β-D-glucosaminidase excretion on the first day of life was significantly raised in polycythemic newborns (P <0.01). Fourteen days after partial plasma exchange the enzyme activity returned to normal. N-acetyl-β-D-glucosaminidase activities in preterm babies with respiratory distress syndrome were significantly (P <0.01) raised on the 1st, 2nd, 4th days and fell sharply to the 14th day. N-acetyl-β-D-glucosaminidase isoenzyme studies revealed that urine samples taken from preterm babies with respiratory distress syndrome in the first week after birth contained increased amounts of intermediate and B isoenzyme forms while there was a concomitant reduction in the amount of the A form present.

Original languageEnglish
Pages (from-to)77-85
Number of pages9
JournalClinica Chimica Acta
Volume195
Issue number1-2
DOIs
Publication statusPublished - Dec 31 1990

Fingerprint

Hexosaminidases
Polycythemia
Newborn Infant
Isoenzymes
Gestational Age
Plasma Exchange
Enzyme activity
Premature Infants
Urine
Parturition
Plasmas
Hypoxia
Enzymes

Keywords

  • Hypoxia
  • Neonate
  • Polycythemia
  • Tubular damage
  • Urinary N-acetyl-β-D-glucosaminidase

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

Cite this

The effect of polycythemia and hypoxia on urinary N-acetyl-β-D-glucosaminidase activity in newborns. / Csáthy, László; Pócsi, I.; Kiss, L.; Balla, G.; Modi, Neena; Price, Robert G.

In: Clinica Chimica Acta, Vol. 195, No. 1-2, 31.12.1990, p. 77-85.

Research output: Contribution to journalArticle

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