In rats with experimental hepatic cirrhosis produced by 8 mth administration of thioacetamide the duration of hexobarbital anaesthesia was examined. One week after discontinuance of the poison the sleeping time was prolonged, corresponding to the reduced metabolism of hexobarbital. By premedication of phenobarbital sodium and norandrostenolone phenylpropionate the sleeping time of the cirrhotic animals was considerably shortened. This is attributed to microsomal enzyme induction occurring in the preserved cells still capable of reaction.
|Translated title of the contribution||The effect of phenobarbital and norandrostenolone phenylpropionate on the duration of hexobarbital anesthesia in rats with thioacetamide induced cirrhosis|
|Number of pages||4|
|Publication status||Published - Jan 1 1973|
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