PHENOBARBITAL ES NOR ANDROSTENOLON PHENYLPROPIONAT HATASA THIOACETAMID CIRRHOSISOS PATKANYOK HEXOBARBITAL ALVASI IDEJERE

Translated title of the contribution: The effect of phenobarbital and norandrostenolone phenylpropionate on the duration of hexobarbital anesthesia in rats with thioacetamide induced cirrhosis

A. Pap, G. Marosi, F. Szarvas

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In rats with experimental hepatic cirrhosis produced by 8 mth administration of thioacetamide the duration of hexobarbital anaesthesia was examined. One week after discontinuance of the poison the sleeping time was prolonged, corresponding to the reduced metabolism of hexobarbital. By premedication of phenobarbital sodium and norandrostenolone phenylpropionate the sleeping time of the cirrhotic animals was considerably shortened. This is attributed to microsomal enzyme induction occurring in the preserved cells still capable of reaction.

Original languageHungarian
Pages (from-to)537-540
Number of pages4
JournalKiserletes Orvostudomany
Volume25
Issue number5
Publication statusPublished - 1973

Fingerprint

Phenylpropionates
Thioacetamide
Nandrolone
Hexobarbital
Phenobarbital
Experimental Liver Cirrhosis
Fibrosis
Anesthesia
Enzyme Induction
Premedication
Poisons

ASJC Scopus subject areas

  • Medicine(all)

Cite this

PHENOBARBITAL ES NOR ANDROSTENOLON PHENYLPROPIONAT HATASA THIOACETAMID CIRRHOSISOS PATKANYOK HEXOBARBITAL ALVASI IDEJERE. / Pap, A.; Marosi, G.; Szarvas, F.

In: Kiserletes Orvostudomany, Vol. 25, No. 5, 1973, p. 537-540.

Research output: Contribution to journalArticle

@article{23edb3ccf5a64d74b1dfc874017d53c9,
title = "PHENOBARBITAL ES NOR ANDROSTENOLON PHENYLPROPIONAT HATASA THIOACETAMID CIRRHOSISOS PATKANYOK HEXOBARBITAL ALVASI IDEJERE",
abstract = "In rats with experimental hepatic cirrhosis produced by 8 mth administration of thioacetamide the duration of hexobarbital anaesthesia was examined. One week after discontinuance of the poison the sleeping time was prolonged, corresponding to the reduced metabolism of hexobarbital. By premedication of phenobarbital sodium and norandrostenolone phenylpropionate the sleeping time of the cirrhotic animals was considerably shortened. This is attributed to microsomal enzyme induction occurring in the preserved cells still capable of reaction.",
author = "A. Pap and G. Marosi and F. Szarvas",
year = "1973",
language = "Hungarian",
volume = "25",
pages = "537--540",
journal = "Kiserletes Orvostudomany",
issn = "0023-1878",
number = "5",

}

TY - JOUR

T1 - PHENOBARBITAL ES NOR ANDROSTENOLON PHENYLPROPIONAT HATASA THIOACETAMID CIRRHOSISOS PATKANYOK HEXOBARBITAL ALVASI IDEJERE

AU - Pap, A.

AU - Marosi, G.

AU - Szarvas, F.

PY - 1973

Y1 - 1973

N2 - In rats with experimental hepatic cirrhosis produced by 8 mth administration of thioacetamide the duration of hexobarbital anaesthesia was examined. One week after discontinuance of the poison the sleeping time was prolonged, corresponding to the reduced metabolism of hexobarbital. By premedication of phenobarbital sodium and norandrostenolone phenylpropionate the sleeping time of the cirrhotic animals was considerably shortened. This is attributed to microsomal enzyme induction occurring in the preserved cells still capable of reaction.

AB - In rats with experimental hepatic cirrhosis produced by 8 mth administration of thioacetamide the duration of hexobarbital anaesthesia was examined. One week after discontinuance of the poison the sleeping time was prolonged, corresponding to the reduced metabolism of hexobarbital. By premedication of phenobarbital sodium and norandrostenolone phenylpropionate the sleeping time of the cirrhotic animals was considerably shortened. This is attributed to microsomal enzyme induction occurring in the preserved cells still capable of reaction.

UR - http://www.scopus.com/inward/record.url?scp=0015892365&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015892365&partnerID=8YFLogxK

M3 - Article

VL - 25

SP - 537

EP - 540

JO - Kiserletes Orvostudomany

JF - Kiserletes Orvostudomany

SN - 0023-1878

IS - 5

ER -