The effect of pentobarbital, chloralhydrate, ether and protoveratrine on the distribution of synaptic vesicles in rat cortical synaptosomes

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Abstract

Rat cortical synaptosomes were incubated in a saline medium. On the addition of pentobarbital, chloralhydrate, ether and protoveratrine a redistribution of synaptic vesicles was revealed by electron microscopy. The anaesthetics decreased the number of synaptic vesicles attached to the presynaptic membrane while protoveratrine increased them. It is assumed that these agents affect the mechanism of vesicle reformation from the synaptosomal membrane and/or vesicle migration towards the synaptic cleft.

Original languageEnglish
Pages (from-to)91-99
Number of pages9
JournalExperimental brain research
Volume33
Issue number1
DOIs
Publication statusPublished - Sep 1 1978

Keywords

  • Anaesthetics
  • Synaptosome
  • Vesicle hypothesis

ASJC Scopus subject areas

  • Neuroscience(all)

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