The effect of pentadecapeptide BPC 157 on inflammatory, non-inflammatory, direct and indirect pain and capsaicin neurotoxicity

P. SikiriĆ, K. Gyires, S. Seiwerth, Z. GrabarevlĆ, R. RuČman, M. Petek, I. RotkviĆ, B. TurkoviĆ, I. UdoviČĆ, V. JagiĆ, B. Mildner, M. Duvnjak, Z. DaniloviĆ, M. Kolega, A. Sallmani, S. DjaČiĆ, M. HanzevaČki, N. Lang, V. SimiČeviĆ, M. VeljaČaV. Orihovac, M. BanIĆ, T. BrkiĆ, G. Buljat, D. PeroviĆ, S. Miše, A. MarovlĆ, J. ŠeparoviĆ, V. CoriĆ, K. BuliĆ, A. Cviko, M. Bura

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Abstract

The anti-nociceptive effects of a newly synthesized pentadecapeptide coded BPC 157 (an essential fragment of new organoprotective gastric juice peptide BPC) was evaluated in comparison with aspirin and morphine reference standards, in various experimental models of indirect/direct nociception and neurotoxicity: writhing (acetic acid/magnesium sulphate), tail pinching, hot-plate, and capsaicin application. BPC 157 administered either in the ng or μg per kg range, intraperitoneally, significantly reduced the reactions in the writhing (inflammatory and non-inflammatory, prostaglandin-dependent and independent) and tail pinching tests. In the hot-plate test, unlike morphine, BPC 157 had no effect on normal animals. However, when given to capsaicin treated rats, BPC 157 strongly reduced capsaicin-allodynia, either given as pretreatment or once daily for 14 days after the capsaicin injection. This reduction in capsaicin's effect could not be obtained when BPC 157 was applied in the presence of established capsaicin-somatosensory neuron degeneration (application only on the 14th day after capsaicin), so it is possible that the effects of BPC 157 could be related specifically to the integrity of capsaicin-sensitive somatosensory neurons and their protection (e.g. primary afferent neurons having small-diameter somata and unmyelinated (C-) or thinly myelinated (A6-) fibres).

Original languageEnglish
Pages (from-to)121-127
Number of pages7
JournalInflammoPharmacology
Volume2
Issue number2
DOIs
Publication statusPublished - Jun 1 1993

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Keywords

  • allodynia
  • capsaicin
  • capsaicin-sensitive somatosensory neurons integrity/protection
  • essential fragment of organoprotective gastric juice peptide BPC
  • hot-plate test
  • inflammatory/non-inflammatory, indirect/direct nociception
  • pentadecapeptide BPC 157
  • tail pinching test
  • writhing (acetic acid/magnesium sulphate)

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Pharmacology (medical)

Cite this

SikiriĆ, P., Gyires, K., Seiwerth, S., GrabarevlĆ, Z., RuČman, R., Petek, M., RotkviĆ, I., TurkoviĆ, B., UdoviČĆ, I., JagiĆ, V., Mildner, B., Duvnjak, M., DaniloviĆ, Z., Kolega, M., Sallmani, A., DjaČiĆ, S., HanzevaČki, M., Lang, N., SimiČeviĆ, V., ... Bura, M. (1993). The effect of pentadecapeptide BPC 157 on inflammatory, non-inflammatory, direct and indirect pain and capsaicin neurotoxicity. InflammoPharmacology, 2(2), 121-127. https://doi.org/10.1007/BF02659088