The effect of partial food deprivation on the astroglia in the dorsal subnucleus of the lateral septum of the rat brain

B. Szoke, Zsuzsanna Lendvai, K. Halasy

Research output: Contribution to journalArticle

Abstract

The effect of 40% partial food deprivation was studied on the immunohistochemically detectable amount of glial fibrillary acidic protein (GFAP) - the specific marker of astroglia - in the dorsal subnucleus of lateral septum (LS) of male, intact and ovariectomized (OVX) female rats. Animals were either fed ad libitum (control) or 40% food deprived for one week, then perfusion-fixed, their brains removed, and serial vibratome sections were processed for the immunocytochemical localization of GFAP. Computeraided densitometry was carried out on digital photographs. The results showed that ovariectomy alone did not exert any effect on the density of GFAPimmunoreactivity (GFAP-IR) as compared to the values detected in intact females. Food deprivation increased the density of GFAP in each experimental group. The difference was most pronounced in males, significant in females and much less in ovariectomized females. Parietal cortex chosen as reference area did not show any increase in the local GFAP-IR.It was previously shown that the dorsal subnucleus of the lateral septum reacts with plastic neurochemical changes to food deprivation. Our results prove that these changes affect not only neuronal but also glial elements.

Original languageEnglish
Pages (from-to)414-425
Number of pages12
JournalActa Biologica Hungarica
Volume64
Issue number4
DOIs
Publication statusPublished - Dec 1 2013

Fingerprint

Septum of Brain
Food Deprivation
Glial Fibrillary Acidic Protein
Astrocytes
brain
Rats
Brain
protein
food
Parietal Lobe
Densitometry
Ovariectomy
Neuroglia
Plastics
photograph
Animals
Perfusion
plastic
Food
effect

Keywords

  • Densitometry
  • Food restriction
  • Glial fibrillary acidic protein
  • Immunocytochemistry
  • Ovariectomy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Neurology

Cite this

The effect of partial food deprivation on the astroglia in the dorsal subnucleus of the lateral septum of the rat brain. / Szoke, B.; Lendvai, Zsuzsanna; Halasy, K.

In: Acta Biologica Hungarica, Vol. 64, No. 4, 01.12.2013, p. 414-425.

Research output: Contribution to journalArticle

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