The effect of neonatal treatment (imprinting) with retinoids (vitamin A or retinoic acid) on the binding capacity of thymic glucocorticoid receptor and uterine estrogen receptor in adult rats

Annamária Gaál, G. Csaba

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The perinatal encounter of the developing receptor and the appropriate hormone results in normal receptor development. In the perinatal critical period the receptors can also bind hormone-like molecules. This can cause false imprinting. Retinol and retinoic acid have receptors which belong to the steroid receptor superfamily. In the present study, receptor assays were used for demonstrating the maximum binding capacity (B(max)) and affinity (K(D)) of thymus glucocorticoid and uterus estrogen receptors of rats, neonatally treated or not treated with retinol or retinoic acid. Neonatal treatment of rats (imprinting) with vitamin A (retinol) increased the B(max) of thymus glucocorticoid receptors (P

Original languageEnglish
Pages (from-to)115-119
Number of pages5
JournalEndocrinology and Metabolism
Volume4
Issue number2
Publication statusPublished - 1997

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Glucocorticoid Receptors
Retinoids
Tretinoin
Vitamin A
Estrogen Receptors
Thymus Gland
Hormones
Retinoic Acid Receptors
Steroid Receptors
Glucocorticoids
Uterus

ASJC Scopus subject areas

  • Endocrinology

Cite this

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abstract = "The perinatal encounter of the developing receptor and the appropriate hormone results in normal receptor development. In the perinatal critical period the receptors can also bind hormone-like molecules. This can cause false imprinting. Retinol and retinoic acid have receptors which belong to the steroid receptor superfamily. In the present study, receptor assays were used for demonstrating the maximum binding capacity (B(max)) and affinity (K(D)) of thymus glucocorticoid and uterus estrogen receptors of rats, neonatally treated or not treated with retinol or retinoic acid. Neonatal treatment of rats (imprinting) with vitamin A (retinol) increased the B(max) of thymus glucocorticoid receptors (P",
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