The effect of microenvironmental factors on the development of myeloma cells

Ágnes Márk, Gergely Varga, Botond Timár, Csilla Kriston, Orsolya Szabó, Linda Deák, A. Matolcsy, G. Barna

Research output: Contribution to journalArticle

Abstract

Multiple myeloma (MM) is a clonal B-cell malignancy characterized by the accumulation of monoclonal plasma cells (PCs) in the bone marrow and other tissues. Although there are several new therapies, MM remains fatal. The interaction between MM cells and the bone marrow microenvironment promotes drug resistance and cancer cells survival. In our present work, we compared the antigen expression pattern of normal and pathological PCs and investigated the possible connections between various surface receptors, adhesion molecules, and recurrent genetic aberrations. We showed that the expression of CD29, CD27, and CD81 is lower in MM cells than in normal PCs. We found correlation of chromosome 11 hyperdiploidity and the decrease of CD27 expression. We demonstrated that MM cells with CD20 positivity also have CD28 expression. Multiple myeloma patients with active CD29 showed better response to treatment. Our results suggest that these changes may result in an alteration of the interaction between stromal cell and MM cell facilitating cell survival and the development of a more aggressive and resistant phenotype.

Original languageEnglish
JournalHematological Oncology
DOIs
Publication statusAccepted/In press - 2016

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Multiple Myeloma
Plasma Cells
Cell Survival
Chromosomes, Human, Pair 11
Stromal Cells
Drug Resistance
Bone Marrow Cells
Neoplasms
B-Lymphocytes
Bone Marrow
Phenotype
Antigens
Therapeutics

Keywords

  • CD20
  • CD27
  • CD29
  • CD81
  • Multiplex myeloma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

The effect of microenvironmental factors on the development of myeloma cells. / Márk, Ágnes; Varga, Gergely; Timár, Botond; Kriston, Csilla; Szabó, Orsolya; Deák, Linda; Matolcsy, A.; Barna, G.

In: Hematological Oncology, 2016.

Research output: Contribution to journalArticle

Márk, Ágnes ; Varga, Gergely ; Timár, Botond ; Kriston, Csilla ; Szabó, Orsolya ; Deák, Linda ; Matolcsy, A. ; Barna, G. / The effect of microenvironmental factors on the development of myeloma cells. In: Hematological Oncology. 2016.
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AU - Deák, Linda

AU - Matolcsy, A.

AU - Barna, G.

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