The effect of methylglyoxal on actin

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Abstract

Studying the gelation of Ehrlich ascites tumor cell extracts at various methyglyoxal concentrations, an increase of the gelled protein fraction, composed mainly of actin, was found at 10-7 M to 10-5 M. When methylglyoxal was added to intact tumor cells, the filamentous portion of cytoplasmic actin was increased at 10-7 M to 10-6 M concentrations. Furthermore, certain functional properties of purified skeletal muscle actin were also affected by μM concentrations of methylglyoxal; the speed of actin polymerization was facilitated and more filamentous actin formed in polymerizing conditions. The possible mode of methylglyoxal action is discussed.

Original languageEnglish
Pages (from-to)617-622
Number of pages6
JournalBiochemical and biophysical research communications
Volume99
Issue number2
DOIs
Publication statusPublished - Mar 31 1981

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ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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