The effect of marihuana (delta-9 tetrahydrocannabinol) on pregnancy in rat

T. Wenger, Z. Arányi, D. Croix, M. Bereczky, G. Tramu

Research output: Contribution to journalArticle

Abstract

The main psychoactive component of marihuana, delta-9 tetrahydrocannabinol (THC), was administered intraperitoneally to pregnant rats. From day one of pregnancy up to the last day 1ug/kg b.w./day of THC was injected. The control group received physiological saline. Out of the 34 THC injected pregnant rats only 7 (21%) had deliveries in time. THC resulted in prolongation of gestation by 1-4 days (avr. 2 days) in 79% of pregnancies. In the latter cases there were more han 40% stillbirths, approx. 25% macerated foetuses. 25-30% were the victims of mother's cannibalism. The results emphasize the significance of marihuana consumption during pregnancy, i.e. fetal development.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalNeuroendocrinology Letters
Volume10
Issue number1
Publication statusPublished - 1988

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Dronabinol
Cannabis
Pregnancy
Cannibalism
Stillbirth
Fetal Development
Fetus
Control Groups

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

The effect of marihuana (delta-9 tetrahydrocannabinol) on pregnancy in rat. / Wenger, T.; Arányi, Z.; Croix, D.; Bereczky, M.; Tramu, G.

In: Neuroendocrinology Letters, Vol. 10, No. 1, 1988, p. 39-43.

Research output: Contribution to journalArticle

Wenger, T. ; Arányi, Z. ; Croix, D. ; Bereczky, M. ; Tramu, G. / The effect of marihuana (delta-9 tetrahydrocannabinol) on pregnancy in rat. In: Neuroendocrinology Letters. 1988 ; Vol. 10, No. 1. pp. 39-43.
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