The effect of marihuana (delta-9 tetrahydrocannabinol) on pregnancy in rat

T. Wenger, Z. Aranyi, D. Croix, M. Bereczky, G. Tramu

Research output: Contribution to journalArticle

Abstract

The main psychoactive component of marihuana, delta-9 tetrahydrocannabinol (THC), was administered intraperitoneally to pregnant rats. From day one of pregnancy up to the last day 1ug/kg b.w./day of THC was injected. The control group received physiological saline. Out of the 34 THC injected pregnant rats only 7 (21%) had deliveries in time. THC resulted in prolongation of gestation by 1-4 days (avr. 2 days) in 79% of pregnancies. In the latter cases there were more han 40% stillbirths, approx. 25% macerated foetuses. 25-30% were the victims of mother's cannibalism. The results emphasize the significance of marihuana consumption during pregnancy, i.e. fetal development.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalNeuroendocrinology Letters
Volume10
Issue number1
Publication statusPublished - Jan 1 1988

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Psychiatry and Mental health

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