It is known that dietary protein restriction slows the progression of chronic renal disease. If daily protein intake is less than 0.5-0.6 g/kgbw, the diet has to be supplemented with essential aminoacids/ketoacids. In this study the authors evaluate the long-term effect of low-protein diet supplemented with ketoacids on the progression of chronic renal failure, calcium and phosphorus metabolism, nutritional status, the complience of patients and the permanent dietary education for the complience. 51 predialysis patients have been treated with ketoacids supplemented low-protein diet during 12-57 months (mean treatment period: 26 months). Serum creatinine raised from 349.72±78.04 μmol/l to 460.66±206.66 μmol/l (27 μmol/l/year or 2.3 μmol/l/month), glomerular filtration rate (GFR) decreased from 21.52±7.84 ml/min to 18.22±7.76 ml/min (0.83 ml/min/year or 0.07 ml/min/month). The slope of 1/serum creatinine versus time was 0.0018 by linear regression analysis. Serum parathormon decreased significantly, but serum calcium and phosphorus did not change. Nutritional status of patients did not change significantly during the follow-up period. Protein intake decreased significantly and remained at this lower level during the treatment period. According to results: low-protein diet supplemented with ketoacids was effective in slowing progression of chronic renal failure, decreased PTH, did not change nutritional status. With permanently and good education it was possible to keep patients on low-protein diet for a long period.
|Translated title of the contribution||The effect of low-protein diet supplemented with ketoacids in patients with chronic renal failure|
|Number of pages||8|
|Publication status||Published - Feb 1 2009|
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