The effect of long-term tilting on capillary supply in rat hindlimb muscles.

O. Hudlicka, G. Dörnyei, E. Monos

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Rats were kept for three weeks tilted head-up at 45 degrees and their capillary supply (capillary density CD, number of capillaries/mm2, and capillary/fibre ratio C/F), fibre density FD, and muscle weights were compared with a group of animals with similarly restricted movement but at horizontal position, and with control freely moving animals. Movement restriction caused loss of muscle (but not body) weight in fast muscles in all rats, and gain of weight in slow postural soleus in the tilted group. Neither of these changes were due to changes in the content of water. Loss of weight was accompanied by increased fibre density indicative of muscle atrophy due to movement restriction. Capillary supply was not affected by movement restriction, but was significantly decreased, particularly in the oxidative part of tibialis anterior and in the soleus of tilted animals (C/F: 1.78 +/- 0.11 vs 2.11 +/- 0.05 and 2.06 +/- 0.08 vs 2.29 +/- 0.10). It is assumed that this reduction might be explained by changes in hemodynamic characteristics of the venous vascular bed due to a chronic increase in hydrostatic pressure load.

Original languageEnglish
Pages (from-to)205-212
Number of pages8
JournalActa Physiologica Hungarica
Volume83
Issue number3
Publication statusPublished - 1995

Fingerprint

Hindlimb
Muscles
Hydrostatic Pressure
Muscular Atrophy
Weight Gain
Blood Vessels
Weight Loss
Hemodynamics
Head
Body Weight
Weights and Measures
Water

ASJC Scopus subject areas

  • Physiology

Cite this

The effect of long-term tilting on capillary supply in rat hindlimb muscles. / Hudlicka, O.; Dörnyei, G.; Monos, E.

In: Acta Physiologica Hungarica, Vol. 83, No. 3, 1995, p. 205-212.

Research output: Contribution to journalArticle

@article{c5927f4ee7ff4efe9553cedc7ba34552,
title = "The effect of long-term tilting on capillary supply in rat hindlimb muscles.",
abstract = "Rats were kept for three weeks tilted head-up at 45 degrees and their capillary supply (capillary density CD, number of capillaries/mm2, and capillary/fibre ratio C/F), fibre density FD, and muscle weights were compared with a group of animals with similarly restricted movement but at horizontal position, and with control freely moving animals. Movement restriction caused loss of muscle (but not body) weight in fast muscles in all rats, and gain of weight in slow postural soleus in the tilted group. Neither of these changes were due to changes in the content of water. Loss of weight was accompanied by increased fibre density indicative of muscle atrophy due to movement restriction. Capillary supply was not affected by movement restriction, but was significantly decreased, particularly in the oxidative part of tibialis anterior and in the soleus of tilted animals (C/F: 1.78 +/- 0.11 vs 2.11 +/- 0.05 and 2.06 +/- 0.08 vs 2.29 +/- 0.10). It is assumed that this reduction might be explained by changes in hemodynamic characteristics of the venous vascular bed due to a chronic increase in hydrostatic pressure load.",
author = "O. Hudlicka and G. D{\"o}rnyei and E. Monos",
year = "1995",
language = "English",
volume = "83",
pages = "205--212",
journal = "Physiology International",
issn = "2498-602X",
publisher = "Akademiai Kiado",
number = "3",

}

TY - JOUR

T1 - The effect of long-term tilting on capillary supply in rat hindlimb muscles.

AU - Hudlicka, O.

AU - Dörnyei, G.

AU - Monos, E.

PY - 1995

Y1 - 1995

N2 - Rats were kept for three weeks tilted head-up at 45 degrees and their capillary supply (capillary density CD, number of capillaries/mm2, and capillary/fibre ratio C/F), fibre density FD, and muscle weights were compared with a group of animals with similarly restricted movement but at horizontal position, and with control freely moving animals. Movement restriction caused loss of muscle (but not body) weight in fast muscles in all rats, and gain of weight in slow postural soleus in the tilted group. Neither of these changes were due to changes in the content of water. Loss of weight was accompanied by increased fibre density indicative of muscle atrophy due to movement restriction. Capillary supply was not affected by movement restriction, but was significantly decreased, particularly in the oxidative part of tibialis anterior and in the soleus of tilted animals (C/F: 1.78 +/- 0.11 vs 2.11 +/- 0.05 and 2.06 +/- 0.08 vs 2.29 +/- 0.10). It is assumed that this reduction might be explained by changes in hemodynamic characteristics of the venous vascular bed due to a chronic increase in hydrostatic pressure load.

AB - Rats were kept for three weeks tilted head-up at 45 degrees and their capillary supply (capillary density CD, number of capillaries/mm2, and capillary/fibre ratio C/F), fibre density FD, and muscle weights were compared with a group of animals with similarly restricted movement but at horizontal position, and with control freely moving animals. Movement restriction caused loss of muscle (but not body) weight in fast muscles in all rats, and gain of weight in slow postural soleus in the tilted group. Neither of these changes were due to changes in the content of water. Loss of weight was accompanied by increased fibre density indicative of muscle atrophy due to movement restriction. Capillary supply was not affected by movement restriction, but was significantly decreased, particularly in the oxidative part of tibialis anterior and in the soleus of tilted animals (C/F: 1.78 +/- 0.11 vs 2.11 +/- 0.05 and 2.06 +/- 0.08 vs 2.29 +/- 0.10). It is assumed that this reduction might be explained by changes in hemodynamic characteristics of the venous vascular bed due to a chronic increase in hydrostatic pressure load.

UR - http://www.scopus.com/inward/record.url?scp=0029434661&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029434661&partnerID=8YFLogxK

M3 - Article

C2 - 8852645

AN - SCOPUS:0029434661

VL - 83

SP - 205

EP - 212

JO - Physiology International

JF - Physiology International

SN - 2498-602X

IS - 3

ER -