The effect of local nitric oxide synthase inhibition on the diameter of pulpal arteriole in dental bond material-induced vasodilation in rat

B. Kispélyi, Zs. Lohinai, I. Iványi, S. MirzaHosseini, I. Nyárasdy, L. Rosivall

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Local application of dental bond materials can cause pulpal vasodilation and hyperemia. Such local hemodynamic changes may be mediated by alterations in the levels of locally generated nitric oxide (NO). In different species systemic administration of NO synthase inhibitors leads to a decrease in pulpal blood flow. In contrast, the local administration of these inhibitors has not been tested yet. Therefore, the effect of locally blocked NO synthase on the internal diameter of rat pulpal arterioles under basal conditions and immediately after dental bond material application was studied by using vitalmicroscopic technique. The NO synthase blocker (l-NAME) was locally administered on a thinned dentine layer of the left lower incisor. l-NAME reduced the diameter of the pulpal arteriole both in basal and after bond material-induced hyperaemic conditions. These data suggest that the local formation of NO may have a significant role in the acute vasodilation induced by bond material application and also in maintenance of basal pulpal arteriolar tone.

Original languageEnglish
Pages (from-to)1367-1374
Number of pages8
JournalLife Sciences
Volume77
Issue number12
DOIs
Publication statusPublished - Aug 5 2005

Fingerprint

Dental Materials
Arterioles
Vasodilation
Nitric Oxide Synthase
Rats
Nitric Oxide
Hyperemia
Dentin
Incisor
Hemodynamics
Maintenance
Blood

Keywords

  • Bond material
  • L-NAME
  • Nitric oxide
  • Pulpal circulation
  • Vitalmicroscopy

ASJC Scopus subject areas

  • Pharmacology

Cite this

The effect of local nitric oxide synthase inhibition on the diameter of pulpal arteriole in dental bond material-induced vasodilation in rat. / Kispélyi, B.; Lohinai, Zs.; Iványi, I.; MirzaHosseini, S.; Nyárasdy, I.; Rosivall, L.

In: Life Sciences, Vol. 77, No. 12, 05.08.2005, p. 1367-1374.

Research output: Contribution to journalArticle

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