The effect of levosimendan during long-term amiodarone treatment in dogs

J. Papp, Piero Pollesello, A. Varró, A. Végh, Eva Udvary

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The haemodynamic and electrophysiological effects of levosimendan were studied in conscious dogs receiving long-term oral amiodarone treatment. Instrumented dogs were administered increasing doses of levosimendan (up to 0.9 μg/kg/min. intravenously) in three successive 30 min. infusions. This schedule was repeated on the 21st day of treatment with oral amiodarone 100 mg/kg/day. The extent of increase in left ventricular systolic pressure (LVSP) and the decrease in left ventricular end-diastolic pressure (LVEDP) seen with levosimendan were similar before and after long-term treatment with amiodarone. The levosimendan-induced increases in isovolumic contraction (+dP/dt) and in left ventricular contractility (dP/dt/P) seen prior to amiodarone administration were augmented during amiodarone treatment, an effect that was statistically significant (P

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalBasic and Clinical Pharmacology and Toxicology
Volume99
Issue number1
DOIs
Publication statusPublished - Jul 2006

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Amiodarone
Dogs
Blood Pressure
Hemodynamics
Ventricular Pressure
Appointments and Schedules
simendan

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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The effect of levosimendan during long-term amiodarone treatment in dogs. / Papp, J.; Pollesello, Piero; Varró, A.; Végh, A.; Udvary, Eva.

In: Basic and Clinical Pharmacology and Toxicology, Vol. 99, No. 1, 07.2006, p. 27-32.

Research output: Contribution to journalArticle

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