The effect of levo-acetyl-carnitine on visual cognitive evoked potentials in the behaving monkey

A. Antal, I. Bodis-Wollner, M. F. Ghilardi, A. Glover, L. Mylin, J. Toldi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We studied acute and chronic effects of levo-acetyl-carnitine (LAC) on event-related potentials (ERPs) in 3 monkeys trained in a "go"/"no-go" visual "oddball" discrimination task. The stimuli were 2.5 cpd sinusoidal gratings differing in their respective orientation only (0° or 45°). Each monkey was trained to release a lever during a prespecified time window. Target stimulus presentation probabilities were between 0.25 and 0.5 ERPs had comparable mean latencies and amplitudes in all monkeys. Primary evoked potentials recorded to either the target or non-target stimulus did not change significantly as a result of LAC treatment. On the other hand, P300 latency decreased following LAC administration, with a maximum occurring in 15-20 min. The major effects of LAC were consistent within each animal and for all three of them.

Original languageEnglish
Pages (from-to)268-274
Number of pages7
JournalElectroencephalography and Clinical Neurophysiology
Volume86
Issue number4
DOIs
Publication statusPublished - Apr 1993

Keywords

  • Cholinergic mechanism
  • Cognition
  • Event-related potentials
  • Levo-acetyl-carnitine (LAC)
  • Neurotransmitter
  • P300
  • Primates

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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