The effect of ischemic preconditioning on redox status during liver resections-randomized controlled trial

Oszkár Hahn, A. Blázovics, Lászlõ Váli, P. Kupcsulik

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background and Objectives: Portal clamping during liver resection decreases intraoperative blood loss, but causes ischemic-reperfusion (I-R) injury. Intermittent portal clamping (IPC) and ischemic preconditioning (IP) decreased I-R injury in animal models. Most of the human studies about IP excluded cirrhotic patients, whose liver is more vulnerable to I-R injury. The effect of IP and IPC during extended liver resection was investigated in this randomized controlled trial, with special respect to cirrhotic patients. Methods: One hundred sixty patients (100 normal liver, 60 cirrhotic) undergoing major liver resection were randomized to receive IPC (15min ischemia, 5min reperfusion), or IP (10min ischemia, 10min reperfusion). Serum oxygen-derived free radicals (ODFR) and antioxidant concentrations (preoperative, after reperfusion and 7th postoperative day), such as "conventional" liver tests (preoperative, 1st, 3rd, and 7th postoperative day) were measured. Results: IP resulted in significantly lower peak ODFR, AST, ALT, and bilirubin levels after liver resection than IPC (P

Original languageEnglish
Pages (from-to)647-653
Number of pages7
JournalJournal of Surgical Oncology
Volume104
Issue number6
DOIs
Publication statusPublished - Nov 1 2011

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Ischemic Preconditioning
Oxidation-Reduction
Randomized Controlled Trials
Constriction
Liver
Reperfusion Injury
Reperfusion
Free Radicals
Ischemia
Oxygen
Bilirubin
Animal Models
Antioxidants
Serum

Keywords

  • antioxidants
  • cirrhosis
  • free radicals
  • ischemia-reperfusion

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

The effect of ischemic preconditioning on redox status during liver resections-randomized controlled trial. / Hahn, Oszkár; Blázovics, A.; Váli, Lászlõ; Kupcsulik, P.

In: Journal of Surgical Oncology, Vol. 104, No. 6, 01.11.2011, p. 647-653.

Research output: Contribution to journalArticle

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