The effect of iron binding on the conformation of transferrin

A small angle X-ray scattering study

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Distance distribution functions, p(r), radii of gyration, R(g), and radii of gyration of cross section, R(q), of apotransferrin, monoferric transferrin, and diferric transferrin have been compared. The alteration of R(g) and R(q) upon iron binding has been determined by a difference method. An unusual feature of the stepwise structural changes of transferrin upon iron saturation is that binding of the first ferric ion is responsible for more than half of the whole change in R(q), whereas R(g) alters significantly only after the binding of the second ferric ion.

Original languageEnglish
Pages (from-to)799-802
Number of pages4
JournalBiophysical Journal
Volume48
Issue number5
Publication statusPublished - 1985

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Transferrin
Iron
X-Rays
Ions
diferric transferrin
apotransferrin

ASJC Scopus subject areas

  • Biophysics

Cite this

The effect of iron binding on the conformation of transferrin : A small angle X-ray scattering study. / Kilár, F.; Simon, I.

In: Biophysical Journal, Vol. 48, No. 5, 1985, p. 799-802.

Research output: Contribution to journalArticle

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