The effect of insulin on the liver cells of newborn rats. An electron microscopic study.

T. C. Thang, M. Gruszczynska, G. Csaba

Research output: Contribution to journalArticle

Abstract

The liver of newborn rats contains neither glycogen nor lipid droplets. These latter, sometimes in fusion, still could be found in the cytoplasm and the nucleus as well, following a five-minute action of insulin at a dose of 0.2 IU/animal. The lipid droplets were in close relationship with the mitochondria. This time the glycogen, either in fields or rosettes, was missing. Thirty minutes after treatment the fields of glycogen could be well seen. The experiments demonstrated an exclusive sequence of events starting with the receptor and its signal insulin on neonatal liver cells and resulting in a morphological picture (involving first lipid droplets, then glycogen), similar to that of the adult liver cells.

Original languageEnglish
Pages (from-to)365-369
Number of pages5
JournalJournal of submicroscopic cytology and pathology
Volume25
Issue number3
Publication statusPublished - Jul 1993

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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