The effect of hypoxia on the lactic dehydrogenase /LDH/ activity of serum and heart muscle of rats

L. Selmeci, A. Farkas, E. Pósch, I. Szelényi, J. Sós

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Abstract

Rats were kept in a low-pressure chamber /simulated altitude of 18,300 ft/ for six hours, to induce hypoxia. The LDH activities in the sera and in the heart muscle extracts were measured. The total LDH activity and the activity of heat stable isozyme in serum elevated significantly in the experimental group. The ratio of the activity of heat stable isozyme related to the total LDH activity has not changed significantly. The LDH activity in the heart muscle extract has slightly decreased in the experimental group but this change was not significant. It has been suggested that as a result of a general cellular damage LDH liberates from the different organs into the sera of rats exposed to hypoxia.

Original languageEnglish
Pages (from-to)649-653
Number of pages5
JournalLife Sciences
Volume6
Issue number6
Publication statusPublished - Mar 15 1967

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Isoenzymes
Muscle
Rats
Myocardium
Oxidoreductases
Milk
Hot Temperature
Serum
Pressure
Hypoxia
heart muscle extract

ASJC Scopus subject areas

  • Pharmacology

Cite this

The effect of hypoxia on the lactic dehydrogenase /LDH/ activity of serum and heart muscle of rats. / Selmeci, L.; Farkas, A.; Pósch, E.; Szelényi, I.; Sós, J.

In: Life Sciences, Vol. 6, No. 6, 15.03.1967, p. 649-653.

Research output: Contribution to journalArticle

Selmeci, L, Farkas, A, Pósch, E, Szelényi, I & Sós, J 1967, 'The effect of hypoxia on the lactic dehydrogenase /LDH/ activity of serum and heart muscle of rats', Life Sciences, vol. 6, no. 6, pp. 649-653.
Selmeci, L. ; Farkas, A. ; Pósch, E. ; Szelényi, I. ; Sós, J. / The effect of hypoxia on the lactic dehydrogenase /LDH/ activity of serum and heart muscle of rats. In: Life Sciences. 1967 ; Vol. 6, No. 6. pp. 649-653.
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