The effect of high mesencephalic transection (Cerveau isole) and pentobarbital on basal forebrain mechanisms of EEG synchronization

F. Obal, G. Benedek, M. Szikszay, F. Obal

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Abstract

A study was made of the effects of high mesencephalic transection (cerveau isole) and low doses of pentobarbital on the cortical synchronizations elicited in acute immobilized cats by low frequency stimulation of the lateral hypothalamus (HL) and nucleus ventralis anterior thalami (VA), and by low and high frequency stimulation of the laterobasal preoptic region (RPO) and olfactory tubercle (TbOf). The results obtained were as follows. The synchronizations induced by basal forebrain stimulations were found to survive in acute cerveau isole cats; moreover, even a facilitation of the synchronizing effect was observed. A gradual facilitation was observed upon TbOf and RPO stimulation, while in the case of VA and HL stimulations, the facilitation appeared immediately after the transection. Low doses of pentobarbital depressed the cortical effects of TbOf stimulation, while an increase of the synchronizing effect of low frequency VA and HL stimulation was found. The observations suggested that the synchronizing mechanism in the ventral part of the basal forebrain (RPO and TbOf) differs from that of the thalamus and HL; the basal forebrain synchronizing mechanism is effective without the contribution of the brain stem; and the mechanism responsible for the synchronizing effect of low frequency HL stimulation is similar as that described for the thalamus.

Original languageEnglish
Pages (from-to)453-468
Number of pages16
JournalActa Physiologica Academiae Scientiarum Hungaricae
Volume53
Issue number4
Publication statusPublished - 1979

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Anterior Thalamic Nuclei
Pentobarbital
Anterior Hypothalamus
Electroencephalography
Thalamus
Hypothalamus
Cats
Cortical Synchronization
Lateral Hypothalamic Area
Brain Stem
Basal Forebrain

ASJC Scopus subject areas

  • Physiology

Cite this

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abstract = "A study was made of the effects of high mesencephalic transection (cerveau isole) and low doses of pentobarbital on the cortical synchronizations elicited in acute immobilized cats by low frequency stimulation of the lateral hypothalamus (HL) and nucleus ventralis anterior thalami (VA), and by low and high frequency stimulation of the laterobasal preoptic region (RPO) and olfactory tubercle (TbOf). The results obtained were as follows. The synchronizations induced by basal forebrain stimulations were found to survive in acute cerveau isole cats; moreover, even a facilitation of the synchronizing effect was observed. A gradual facilitation was observed upon TbOf and RPO stimulation, while in the case of VA and HL stimulations, the facilitation appeared immediately after the transection. Low doses of pentobarbital depressed the cortical effects of TbOf stimulation, while an increase of the synchronizing effect of low frequency VA and HL stimulation was found. The observations suggested that the synchronizing mechanism in the ventral part of the basal forebrain (RPO and TbOf) differs from that of the thalamus and HL; the basal forebrain synchronizing mechanism is effective without the contribution of the brain stem; and the mechanism responsible for the synchronizing effect of low frequency HL stimulation is similar as that described for the thalamus.",
author = "F. Obal and G. Benedek and M. Szikszay and F. Obal",
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AU - Obal, F.

PY - 1979

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