The effect of heparin and its components on frog heart

G. Csaba, Cecilia Horváth

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Abstract

Heparin inhibits the contractions of frog heart. The effect is abolished by calcium but not by atropine or adrenaline. Heparin is able to annul the systolic contracture caused by high calcium concentration. Of the heparin components, the glucuronic acid is responsible for its effect. Glucosamine is ineffective alone, but potentiates the glucosamine effect. Sulfate groupings have most probably a similar effect. The heparin antagonist protamine sulfate also inhibits the beating. The mechanism of the observed effects is discussed.

Original languageEnglish
Pages (from-to)1075-1080
Number of pages6
JournalBiochemical Pharmacology
Volume12
Issue number10
Publication statusPublished - Oct 1963

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ASJC Scopus subject areas

  • Pharmacology
  • Biochemistry

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