The effect of gastroduodenal xylocaine on the basal pancreatic secretion in rats

A. Pap, H. Sarles

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effect of intragastric and intraduodenal xylocaine on the pancreatic secretion was investigated in conscious rats. A 1% xylocaine infusion strongly decreased pancreatic protein output and flow during recirculation of pancreatic juice into the duodenum, but it diminished only moderately the increase in the secretion seen after its diversion and after duodenal infusion of soybean trypsin inhibitor. Moderate inhibition appeared during prolonged diversion of pancreatic juice. The response to exogenous CCK + secretin was not modified. The results indicate that during recirculation of the pancreatic juice, which is more physiologic than its diversion from the duodenum, the neural control may play a significant role.

Original languageEnglish
Pages (from-to)187-196
Number of pages10
JournalActa medica Academiae Scientiarum Hungaricae
Volume36
Issue number2
Publication statusPublished - Dec 1 1979

ASJC Scopus subject areas

  • Medicine(all)

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