The effect of femtosecond laser capsulotomy on the development of posterior capsule opacification

Illés Kovács, Kinga Kránitz, Gábor L. Sándor, Michael C. Knorz, Eric D. Donnenfeld, Rudy M. Nuijts, Zoltán Z. Nagy

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27 Citations (Scopus)


PURPOSE: To evaluate and compare the effects of femtosecond laser-assisted anterior capsulotomy and manual anterior capsulorhexis on posterior capsule opacification (PCO) development. METHODS: Femtosecond laser-assisted anterior capsulotomy was performed in 40 eyes of 40 patients (FS group) and manual anterior capsulorhexis was performed in 39 eyes of 39 patients (CCC group). An AcrySof one-piece hydrophobic acrylic intraocular lens (Alcon Laboratories, Inc., Fort Worth, TX) was implanted in all eyes. The PCO level was measured using Open-Access Systematic Capsule Assessment (OSCA) software 18 to 26 months after surgery. Postoperative intraocular lens position (ie, tilt and decentration) was measured using Scheimpflug images (Pentacam; Oculus Optikgeräte GmbH, Wetzlar, Germany). RESULTS: There was no statistically significant difference in age, axial length, and follow-up time between the two groups (P > .05). Vertical tilt, horizontal and total decentration of intraocular lenses, and PCO proved to be significantly higher in the CCC group (P = .03, .04, .03, and .01, respectively). After adjusting for axial length and follow-up time, manual anterior capsulorhexis was found to be a significant predictor of higher PCO scores in the multivariable regression model (β: 0.33; 95% CI: 0.01 to 0.65; P = .04). Vertical tilt affected PCO scores after adjusting for axial length and followup time (β: 0.07; 95% CI: 0.01 to 0.12; P = .02). No capsulotomies were performed during follow-up in either group. CONCLUSIONS: Femtosecond laser-assisted anterior capsulotomy proved to be a safe procedure for postoperative PCO rates. Due to better intraocular lens position, femtosecond laser-assisted anterior capsulotomy resulted in slightly decreased PCO scores; however, evaluating its clinical significance requires further studies.

Original languageEnglish
Pages (from-to)154-158
Number of pages5
JournalJournal of Refractive Surgery
Issue number3
Publication statusPublished - Mar 2014


ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

Cite this

Kovács, I., Kránitz, K., Sándor, G. L., Knorz, M. C., Donnenfeld, E. D., Nuijts, R. M., & Nagy, Z. Z. (2014). The effect of femtosecond laser capsulotomy on the development of posterior capsule opacification. Journal of Refractive Surgery, 30(3), 154-158.