The effect of "facteur thymique serique" (FTS) on catecholamine and serotonin neurotransmission in discrete brain regions of mice.

L. Vécsei, M. Faludi, J. Najbauer

Research output: Contribution to journalArticle

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Abstract

The dose-related effect of Facteur Thymique Serique (FTS) on hypothalamic, mesencephalic and striatal neurotransmission were investigated after intracerebroventricular (icv) administration. FTS pretreatment with dose of 1 microgram (icv) increased the mesencephalic serotonin content, while failed to influence the hypothalamic and striatal serotonin levels. The nonapeptide in a dose of 0.1 microgram (icv) decreased the hypothalamic, while in a dose of 1 microgram the hypothalamic and also the mesencephalic dopamine content, but did not influence the striatal dopamine level. FTS in a dose of 1 microgram (icv) significantly decreased the hypothalamic noradrenaline level, but did not influence the noradrenaline content of the mesencephalon and striatum. These results suggest that FTS is able to modify central neurotransmission.

Original languageEnglish
Pages (from-to)129-132
Number of pages4
JournalActa Physiologica Hungarica
Volume69
Issue number1
Publication statusPublished - 1987

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Circulating Thymic Factor
Corpus Striatum
Synaptic Transmission
Catecholamines
Serotonin
Brain
Dopamine
Norepinephrine
Mesencephalon

ASJC Scopus subject areas

  • Physiology

Cite this

The effect of "facteur thymique serique" (FTS) on catecholamine and serotonin neurotransmission in discrete brain regions of mice. / Vécsei, L.; Faludi, M.; Najbauer, J.

In: Acta Physiologica Hungarica, Vol. 69, No. 1, 1987, p. 129-132.

Research output: Contribution to journalArticle

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