The effect of etodolac on bile salt and histamine-mediated gastric mucosal injury in the rat

Omar M.E. Abdel Salam, Siham El-Shenawy, Seham El-Batran, Mahmoud S. Arbid, Gyula Mózsik

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Abstract

The effect of the selective cyclo-oxygenase-type-2 (COX-2) inhibitor etodolac on gastric mucosal integrity and gastric acid secretion was investigated in the rat. Etodolac was given in doses comparable with those being used in man for therapy of rheumatic conditions. The effect of etodolac was studied in the presence of a mild barrier breaker and in the presence of increased rates of endogenous acid secretion. In conscious pylorus-ligated rats, etodolac given intragastrically in 16 or 32 mg/kg for 3 h did not by itself give rise to visible gastric mucosal injury. Etodolac, however, exacerbated gastric mucosal injury evoked by intragastric application of acidified sodium taurocholate (5 mM in 150 mM HC1) in a dose-dependent manner. This effect of etodolac was independent of changes in gastric acid secretory responses. In rats whose gastric acid secretion was stimulated by intraperitoneal histamine (5 mg/kg), and etodolac (given i.g. in doses of 16 or 32 mg/kg) also increased gastric mucosal injury caused by histamine dose-dependently in the 3-h pylorus-ligated rats. Etodolac decreased gastric mucus in the saline- and in the sodium taurocholate-treated rats. In urethane-anaesthetized acute gastric fistula rats, intragastric etodolac (32 mg/kg) did not modify basal gastric acid secretion. Our data suggest that etodolac, a selective COX-2 inhibitor, impairs gastric mucosal resistance and can exacerbate gastric mucosal injury caused by other mucosal barrier breaking agents. Cyclooxygenase type-2 thus contributes to the gastric mucosal defences.

Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalJournal of Physiology Paris
Volume95
Issue number1-6
DOIs
Publication statusPublished - Nov 12 2001

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Keywords

  • COX-2
  • Etodolac
  • Gastric acid
  • Gastric ulcer
  • Rat stomach

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

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