The effect of erythropoietin on the cellular defence mechanism of red blood cells in children with chronic renal failure

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Abstract

The glutathione redox system, haemoglobin (Hb) oxidation, the activity of antioxidant enzymes and the lipid peroxidation product malonyl dialdehyde (MDA) were studied in red blood cells (RBCs) during administration of recombinant human erythropoietin (rhEPO) over 12 weeks in ten children maintained on haemodialysis. A rapid increase in the reticulocyte count was accompanied by a slower rise in total Hb concentration. The mean level of oxidized glutathione (GSSG) increased from 13.2±5.3 nmol/g Hb to 56.7±15.8 nmol/g Hb 4 weeks after the start of rhEPO (P

Original languageEnglish
Pages (from-to)536-541
Number of pages6
JournalPediatric Nephrology
Volume6
Issue number6
DOIs
Publication statusPublished - Nov 1992

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Erythropoietin
Chronic Kidney Failure
Hemoglobins
Erythrocytes
Glutathione Disulfide
Reticulocyte Count
Lipid Peroxidation
Oxidation-Reduction
Glutathione
Renal Dialysis
Antioxidants
Enzymes

Keywords

  • Erythropoietin
  • Glutathione redox ratio
  • Haemoglobin oxidation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

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title = "The effect of erythropoietin on the cellular defence mechanism of red blood cells in children with chronic renal failure",
abstract = "The glutathione redox system, haemoglobin (Hb) oxidation, the activity of antioxidant enzymes and the lipid peroxidation product malonyl dialdehyde (MDA) were studied in red blood cells (RBCs) during administration of recombinant human erythropoietin (rhEPO) over 12 weeks in ten children maintained on haemodialysis. A rapid increase in the reticulocyte count was accompanied by a slower rise in total Hb concentration. The mean level of oxidized glutathione (GSSG) increased from 13.2±5.3 nmol/g Hb to 56.7±15.8 nmol/g Hb 4 weeks after the start of rhEPO (P",
keywords = "Erythropoietin, Glutathione redox ratio, Haemoglobin oxidation",
author = "S. T{\'u}ri and I. N{\'e}meth and I. Varga and Tibor Bodrogi and B. Matkovics",
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T1 - The effect of erythropoietin on the cellular defence mechanism of red blood cells in children with chronic renal failure

AU - Túri, S.

AU - Németh, I.

AU - Varga, I.

AU - Bodrogi, Tibor

AU - Matkovics, B.

PY - 1992/11

Y1 - 1992/11

N2 - The glutathione redox system, haemoglobin (Hb) oxidation, the activity of antioxidant enzymes and the lipid peroxidation product malonyl dialdehyde (MDA) were studied in red blood cells (RBCs) during administration of recombinant human erythropoietin (rhEPO) over 12 weeks in ten children maintained on haemodialysis. A rapid increase in the reticulocyte count was accompanied by a slower rise in total Hb concentration. The mean level of oxidized glutathione (GSSG) increased from 13.2±5.3 nmol/g Hb to 56.7±15.8 nmol/g Hb 4 weeks after the start of rhEPO (P

AB - The glutathione redox system, haemoglobin (Hb) oxidation, the activity of antioxidant enzymes and the lipid peroxidation product malonyl dialdehyde (MDA) were studied in red blood cells (RBCs) during administration of recombinant human erythropoietin (rhEPO) over 12 weeks in ten children maintained on haemodialysis. A rapid increase in the reticulocyte count was accompanied by a slower rise in total Hb concentration. The mean level of oxidized glutathione (GSSG) increased from 13.2±5.3 nmol/g Hb to 56.7±15.8 nmol/g Hb 4 weeks after the start of rhEPO (P

KW - Erythropoietin

KW - Glutathione redox ratio

KW - Haemoglobin oxidation

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