The effect of diazepam and promethazine treatment during pregnancy on the somatic development of human offspring

E. Czeizel, B. A. Szegal, J. M. Joffe, J. Rácz

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The postnatal longitudinal somatic, neurological, mental, and behavioral developments were studied in children at birth, 8, 15, and 24 months of life, whose mothers were treated during pregnancy with clinical doses of diazepam (n = 126) and promethazine (n = 127) and whose mothers were unexposed. The latter group was differentiated in negative (n = 256) and positive (n = 102) control children. The positive control group involved mothers who had pregnancy complications similar to those of mothers in the drug groups but who were not treated with CNS-active drugs during pregnancy. It is very difficult to recruit persons for the study and control groups who are appropriate for comparative evaluation. Only firstborns and the so-called 'normal' newborn infants were studied; children with low birth weight, major abnormalities, severe neonatal diseases, etc., were excluded. In this article the study design, study materials, and somatic (weight, length, head circumference) development are described. At birth, children had a lower weight in the diazepam group, but it was not noted at the eighth month of postnatal life. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)157-167
Number of pages11
JournalNeurotoxicology and Teratology
Volume21
Issue number2
DOIs
Publication statusPublished - Mar 1999

Fingerprint

Promethazine
Human Development
Diazepam
Mothers
Pregnancy
Parturition
Weights and Measures
Pharmaceutical Preparations
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Control Groups
Pregnancy Complications
Low Birth Weight Infant
Therapeutics
Head
Newborn Infant

Keywords

  • Diazepam
  • Prenatal exposure
  • Promethazine
  • Somatic development

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neuroscience(all)
  • Toxicology

Cite this

The effect of diazepam and promethazine treatment during pregnancy on the somatic development of human offspring. / Czeizel, E.; Szegal, B. A.; Joffe, J. M.; Rácz, J.

In: Neurotoxicology and Teratology, Vol. 21, No. 2, 03.1999, p. 157-167.

Research output: Contribution to journalArticle

@article{07c908b79c2b440e8fd79017612efd65,
title = "The effect of diazepam and promethazine treatment during pregnancy on the somatic development of human offspring",
abstract = "The postnatal longitudinal somatic, neurological, mental, and behavioral developments were studied in children at birth, 8, 15, and 24 months of life, whose mothers were treated during pregnancy with clinical doses of diazepam (n = 126) and promethazine (n = 127) and whose mothers were unexposed. The latter group was differentiated in negative (n = 256) and positive (n = 102) control children. The positive control group involved mothers who had pregnancy complications similar to those of mothers in the drug groups but who were not treated with CNS-active drugs during pregnancy. It is very difficult to recruit persons for the study and control groups who are appropriate for comparative evaluation. Only firstborns and the so-called 'normal' newborn infants were studied; children with low birth weight, major abnormalities, severe neonatal diseases, etc., were excluded. In this article the study design, study materials, and somatic (weight, length, head circumference) development are described. At birth, children had a lower weight in the diazepam group, but it was not noted at the eighth month of postnatal life. Copyright (C) 1999 Elsevier Science Inc.",
keywords = "Diazepam, Prenatal exposure, Promethazine, Somatic development",
author = "E. Czeizel and Szegal, {B. A.} and Joffe, {J. M.} and J. R{\'a}cz",
year = "1999",
month = "3",
doi = "10.1016/S0892-0362(98)00043-9",
language = "English",
volume = "21",
pages = "157--167",
journal = "Neurotoxicology and Teratology",
issn = "0892-0362",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - The effect of diazepam and promethazine treatment during pregnancy on the somatic development of human offspring

AU - Czeizel, E.

AU - Szegal, B. A.

AU - Joffe, J. M.

AU - Rácz, J.

PY - 1999/3

Y1 - 1999/3

N2 - The postnatal longitudinal somatic, neurological, mental, and behavioral developments were studied in children at birth, 8, 15, and 24 months of life, whose mothers were treated during pregnancy with clinical doses of diazepam (n = 126) and promethazine (n = 127) and whose mothers were unexposed. The latter group was differentiated in negative (n = 256) and positive (n = 102) control children. The positive control group involved mothers who had pregnancy complications similar to those of mothers in the drug groups but who were not treated with CNS-active drugs during pregnancy. It is very difficult to recruit persons for the study and control groups who are appropriate for comparative evaluation. Only firstborns and the so-called 'normal' newborn infants were studied; children with low birth weight, major abnormalities, severe neonatal diseases, etc., were excluded. In this article the study design, study materials, and somatic (weight, length, head circumference) development are described. At birth, children had a lower weight in the diazepam group, but it was not noted at the eighth month of postnatal life. Copyright (C) 1999 Elsevier Science Inc.

AB - The postnatal longitudinal somatic, neurological, mental, and behavioral developments were studied in children at birth, 8, 15, and 24 months of life, whose mothers were treated during pregnancy with clinical doses of diazepam (n = 126) and promethazine (n = 127) and whose mothers were unexposed. The latter group was differentiated in negative (n = 256) and positive (n = 102) control children. The positive control group involved mothers who had pregnancy complications similar to those of mothers in the drug groups but who were not treated with CNS-active drugs during pregnancy. It is very difficult to recruit persons for the study and control groups who are appropriate for comparative evaluation. Only firstborns and the so-called 'normal' newborn infants were studied; children with low birth weight, major abnormalities, severe neonatal diseases, etc., were excluded. In this article the study design, study materials, and somatic (weight, length, head circumference) development are described. At birth, children had a lower weight in the diazepam group, but it was not noted at the eighth month of postnatal life. Copyright (C) 1999 Elsevier Science Inc.

KW - Diazepam

KW - Prenatal exposure

KW - Promethazine

KW - Somatic development

UR - http://www.scopus.com/inward/record.url?scp=0033018179&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033018179&partnerID=8YFLogxK

U2 - 10.1016/S0892-0362(98)00043-9

DO - 10.1016/S0892-0362(98)00043-9

M3 - Article

C2 - 10192276

AN - SCOPUS:0033018179

VL - 21

SP - 157

EP - 167

JO - Neurotoxicology and Teratology

JF - Neurotoxicology and Teratology

SN - 0892-0362

IS - 2

ER -