The effect of diabetes on the activities of the peroxide metabolism enzymes

B. Matkovics, I. Varga Sz., L. Szabo, H. Witas

Research output: Contribution to journalArticle

171 Citations (Scopus)

Abstract

The lipid peroxidation and (of the peroxide metabolism enzymes) the catalase, superoxide dismutase and glutathione peroxidase activities were determined in red blood cell hemolysates from 20- to 35-year-old human diabetics of both sexes. The results were compared with the values for normal controls from the same age group. The diabetic hemolysates displayed significantly higher glutathione peroxidase and significantly lower superoxide dismutase activities. The lipid peroxidation too was significantly higher in the diabetic hemolysates. Diabetes was induced with alloxan or streptozotocin in rats, and the enzyme activities of the blood and organ homogenates were similarly compared; in these cases the total peroxidase activity. In experimental diabetes the previously observed phenomenon of oxidative stress was confirmed; this may serve as a logical explanation for the occurrence of the later diabetic damage.

Original languageEnglish
Pages (from-to)77-79
Number of pages3
JournalHormone and Metabolic Research
Volume14
Issue number2
Publication statusPublished - 1982

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Peroxides
Medical problems
Glutathione Peroxidase
Metabolism
Lipid Peroxidation
Superoxide Dismutase
Blood
Lipids
Alloxan
Oxidative stress
Lipid Peroxides
Enzyme activity
Enzymes
Streptozocin
Catalase
Peroxidase
Rats
Reference Values
Oxidative Stress
Age Groups

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

The effect of diabetes on the activities of the peroxide metabolism enzymes. / Matkovics, B.; Varga Sz., I.; Szabo, L.; Witas, H.

In: Hormone and Metabolic Research, Vol. 14, No. 2, 1982, p. 77-79.

Research output: Contribution to journalArticle

Matkovics, B. ; Varga Sz., I. ; Szabo, L. ; Witas, H. / The effect of diabetes on the activities of the peroxide metabolism enzymes. In: Hormone and Metabolic Research. 1982 ; Vol. 14, No. 2. pp. 77-79.
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