In the majority of glucocorticoid-resistant receptor containing variants of A9HT cells, the number of dot chromosomes was found to be significantly higher than in the parent cells. The higher number of dot chromosomes, however, did not always correlate with the resistance of L cells to dexamethasone. The formation of dot chromosomes was not the consequence of dexamethasone-induced chromosome breaks. Dot chromosome formation could not be induced by dexamethasone in human diploid cells. It seems likely that dexamethasone can select for A9HT cells with higher numbers of dot chromosomes.
|Number of pages||11|
|Journal||Cytogenetics and Cell Genetics|
|Publication status||Published - Jan 1 1979|
ASJC Scopus subject areas
- Cell Biology