The effect of D-penicillamine on CCl4-induced experimental liver cirrhosis

Z. Schaff, K. Lapis, B. Szende, A. Jeney, P. Gergely, K. Simon, A. Divald, F. Timar, J. Major

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The effect of D-penicillamine (Pe) on liver fibrosis-cirrhosis induced by chronic CCl4 and phenobarbital (Pb) administration in Fischer 344 male rats was studied. Morphometric analysis did not reveal a decrease in the amount of connective tissue fibers after Pe-treatment. Compared to the CCl4 and Pb-treated control groups, Pe had no significant effect on the concentrations of hydroxyproline, a parameter of collagen degradation, either, however, it increased the glycosaminoglycan concentrations. Lymphocyte stimulation by Con-A in the Pe-treated groups did not differ from that of the CCl4 and Pb-treated ones. According to our studies, Pe-treatment was ineffective in rats with liver fibrosis-cirrhosis induced by CCl4 and Pb administration. It seems that Pe can be effective only in the cirrhosis types accompanied by a considerable copper accumulation due to suppression of the toxic effects of copper.

Original languageEnglish
Pages (from-to)111-120
Number of pages10
JournalExperimental Pathology
Volume43
Issue number1-2
Publication statusPublished - 1991

Fingerprint

Experimental Liver Cirrhosis
Penicillamine
Phenobarbital
Liver Cirrhosis
Liver
Rats
Copper
Lymphocytes
Poisons
Hydroxyproline
Lymphocyte Activation
Glycosaminoglycans
Connective Tissue
Fibrosis
Collagen
Tissue
Degradation
Control Groups
Fibers

Keywords

  • CCl, liver cirrhosis
  • Cirrhosis, liver
  • D-penicillamine
  • Liver cirrhosis
  • Phenobarbital, liver cirrhosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

The effect of D-penicillamine on CCl4-induced experimental liver cirrhosis. / Schaff, Z.; Lapis, K.; Szende, B.; Jeney, A.; Gergely, P.; Simon, K.; Divald, A.; Timar, F.; Major, J.

In: Experimental Pathology, Vol. 43, No. 1-2, 1991, p. 111-120.

Research output: Contribution to journalArticle

@article{dcb8497f4fb043bd9afaf5ddf6f053a9,
title = "The effect of D-penicillamine on CCl4-induced experimental liver cirrhosis",
abstract = "The effect of D-penicillamine (Pe) on liver fibrosis-cirrhosis induced by chronic CCl4 and phenobarbital (Pb) administration in Fischer 344 male rats was studied. Morphometric analysis did not reveal a decrease in the amount of connective tissue fibers after Pe-treatment. Compared to the CCl4 and Pb-treated control groups, Pe had no significant effect on the concentrations of hydroxyproline, a parameter of collagen degradation, either, however, it increased the glycosaminoglycan concentrations. Lymphocyte stimulation by Con-A in the Pe-treated groups did not differ from that of the CCl4 and Pb-treated ones. According to our studies, Pe-treatment was ineffective in rats with liver fibrosis-cirrhosis induced by CCl4 and Pb administration. It seems that Pe can be effective only in the cirrhosis types accompanied by a considerable copper accumulation due to suppression of the toxic effects of copper.",
keywords = "CCl, liver cirrhosis, Cirrhosis, liver, D-penicillamine, Liver cirrhosis, Phenobarbital, liver cirrhosis",
author = "Z. Schaff and K. Lapis and B. Szende and A. Jeney and P. Gergely and K. Simon and A. Divald and F. Timar and J. Major",
year = "1991",
language = "English",
volume = "43",
pages = "111--120",
journal = "Experimental and Toxicologic Pathology",
issn = "0940-2993",
publisher = "Urban und Fischer Verlag Jena",
number = "1-2",

}

TY - JOUR

T1 - The effect of D-penicillamine on CCl4-induced experimental liver cirrhosis

AU - Schaff, Z.

AU - Lapis, K.

AU - Szende, B.

AU - Jeney, A.

AU - Gergely, P.

AU - Simon, K.

AU - Divald, A.

AU - Timar, F.

AU - Major, J.

PY - 1991

Y1 - 1991

N2 - The effect of D-penicillamine (Pe) on liver fibrosis-cirrhosis induced by chronic CCl4 and phenobarbital (Pb) administration in Fischer 344 male rats was studied. Morphometric analysis did not reveal a decrease in the amount of connective tissue fibers after Pe-treatment. Compared to the CCl4 and Pb-treated control groups, Pe had no significant effect on the concentrations of hydroxyproline, a parameter of collagen degradation, either, however, it increased the glycosaminoglycan concentrations. Lymphocyte stimulation by Con-A in the Pe-treated groups did not differ from that of the CCl4 and Pb-treated ones. According to our studies, Pe-treatment was ineffective in rats with liver fibrosis-cirrhosis induced by CCl4 and Pb administration. It seems that Pe can be effective only in the cirrhosis types accompanied by a considerable copper accumulation due to suppression of the toxic effects of copper.

AB - The effect of D-penicillamine (Pe) on liver fibrosis-cirrhosis induced by chronic CCl4 and phenobarbital (Pb) administration in Fischer 344 male rats was studied. Morphometric analysis did not reveal a decrease in the amount of connective tissue fibers after Pe-treatment. Compared to the CCl4 and Pb-treated control groups, Pe had no significant effect on the concentrations of hydroxyproline, a parameter of collagen degradation, either, however, it increased the glycosaminoglycan concentrations. Lymphocyte stimulation by Con-A in the Pe-treated groups did not differ from that of the CCl4 and Pb-treated ones. According to our studies, Pe-treatment was ineffective in rats with liver fibrosis-cirrhosis induced by CCl4 and Pb administration. It seems that Pe can be effective only in the cirrhosis types accompanied by a considerable copper accumulation due to suppression of the toxic effects of copper.

KW - CCl, liver cirrhosis

KW - Cirrhosis, liver

KW - D-penicillamine

KW - Liver cirrhosis

KW - Phenobarbital, liver cirrhosis

UR - http://www.scopus.com/inward/record.url?scp=0026331178&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026331178&partnerID=8YFLogxK

M3 - Article

VL - 43

SP - 111

EP - 120

JO - Experimental and Toxicologic Pathology

JF - Experimental and Toxicologic Pathology

SN - 0940-2993

IS - 1-2

ER -