The effect of cytosine arabinoside on the multiplication of cytomegalovirus and on the formation of virus induced intracellular antigens

L. Vaczi, E. Gonczol

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Cytomegalovirus (CMV) induced intracellular antigens have a regular sequence of development. In the presence of cytosine arabinoside (ara C) antigens only appeared in the form of diffusely distributed small granules in the nucleus; however, ultrasonically disrupted cells yielded no detectable infectious virus. The appearance of cytopathic changes depended on the amount of virus used for inoculation. With an inoculum of 3 to 5 TCD50/cell, de novo DNA synthesis began at 12-24 hr after infection and even continued beyond 36 hr. In the presence of ara C added in the course of DNA synthesis, the existing viral genomes developed into mature virions and all the antigen components appeared.

Original languageEnglish
Pages (from-to)189-195
Number of pages7
JournalActa virologica
Volume17
Issue number3
Publication statusPublished - Dec 1 1973

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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