The effect of cytoplasmic Ca2+ signal on the redox state of mitochondrial pyridine nucleotides

András Spät, János G. Pitter

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

As first observed in rat adrenal glomerulosa cells, cytoplasmic Ca 2+ signal, induced by K+, angiotensin II or vasopressin, evokes an increase in the level of reduced mitochondrial pyridine nucleotides, NADH and NADPH. Prostaglandin F2α and extracellular ATP exert similar effects in rat ovarian luteal cells. This coupling of cytoplasmic Ca2+ concentration and mitochondrial metabolism occurs also when the stimuli are applied at physiological concentration and under conditions when no formation of high-Ca2+ perimitochondrial microdomains may be presumed. We present evidence that low submicromolar Ca2+ signals in the cytoplasm can increase mitochondrial Ca2+ concentration and activate mitochondrial dehydrogenation processes. Several observations support the assumption that intramitochondrial Ca2+ signals play a significant role in the stimulation of steroid hormone production.

Original languageEnglish
Pages (from-to)115-118
Number of pages4
JournalMolecular and Cellular Endocrinology
Volume215
Issue number1-2
DOIs
Publication statusPublished - Feb 27 2004

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Keywords

  • Angiotensin II
  • Confocal
  • Glomerulosa cells
  • Luteal cells
  • Mitochondrial calcium
  • NAD(P)H
  • Potassium
  • Prostaglandin F
  • Pyridine nucleotides

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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