In short term tissue cultures Dibutyrl cAMP inhibits the Cortisone induced degranulation of mast cells. The effect of Methylxanthine was found to be similar but developed at a slower rate. The increase of cAMP level also affected the maturation of mast cells, as the ratio of cells of mixed granulation increased, compared to the alcian blue and safranin-positive cells. This indicates inhibition of the maturation of mast cells, which in the present model inhibited degranulation.
|Number of pages||4|
|Journal||Acta Biologica Academiae Scientiarum Hungaricae|
|Publication status||Published - 1977|
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)