The effect of cyclic AMP on the maturation and degranulation of mast cells

G. Csaba, O. Torok

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Abstract

In short term tissue cultures Dibutyrl cAMP inhibits the Cortisone induced degranulation of mast cells. The effect of Methylxanthine was found to be similar but developed at a slower rate. The increase of cAMP level also affected the maturation of mast cells, as the ratio of cells of mixed granulation increased, compared to the alcian blue and safranin-positive cells. This indicates inhibition of the maturation of mast cells, which in the present model inhibited degranulation.

Original languageEnglish
Pages (from-to)153-156
Number of pages4
JournalActa Biologica Academiae Scientiarum Hungaricae
Volume28
Issue number2
Publication statusPublished - 1977

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ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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