The effect of CP-96,345, a non-peptide substance-P antagonist, on thermoregulation and the development of endotoxin-fever in rats

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6 Citations (Scopus)

Abstract

1. Substance-P (SP) has been shown to induce a regulated rise in body temperature when injected into one of the lateral cerebral ventricles of rats. 2. The non-peptide antagonist of SP (CP-96,345) decreased the SP-induced rise in core temperature and, when given prior to an intravenous endotoxin injection, it also attenuated the febrile response to endotoxin.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalJournal of Thermal Biology
Volume25
Issue number1-2
DOIs
Publication statusPublished - Feb 1 2000

Keywords

  • CP-96,345
  • Endotoxin
  • Fever
  • Substance-P
  • Substance-P non-peptide antagonist
  • Thermoregulation

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Agricultural and Biological Sciences(all)
  • Developmental Biology

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