The effect of chronic otitis media on the immunoreactivity of human inner ear

I. Jókay, Z. Papp, Gy Soós, I. Sziklai, B. Dezsö

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Twenty temporal bones (TBs) were removed from autopsy cases and prepared for immunohistochemical examination. Ten TBs were free of ear disease whereas the other ten TBs showed the signs of chronic otitis media. Expression of markers for monocyte-macrophages (25F9, 27E10) and natural killer cells (anti-Leu-11) was examined immunohistochemically. There were no specific positive stainings with 25F9 or anti-Leu-11 antibodies in any of the specimens. Staining for 27E10 was found to be negative in each section obtained from normal cochlea. However, 27E10 positivity was detected in three of ten TBs with signs of chronic ear inflammation. This positivity can be explained by two theories: (1) activated monocytes can enter the inner ear from the systemic circulation as a consequence of chronic antigen challenge; (2) mesothelial cells could become activated as a result of a cross-reaction, with resultant positivity. Development of sensorineural hearing loss in some cases of chronic otitis media may be due to these immunological reactions.

Original languageEnglish
Pages (from-to)529-532
Number of pages4
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume258
Issue number10
DOIs
Publication statusPublished - Dec 1 2001

Keywords

  • Chronic otitis media
  • Human temporal bone
  • Immunohistochemistry
  • Monocyte-macrophage markers
  • Sensorineural hearing loss

ASJC Scopus subject areas

  • Otorhinolaryngology

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