The effect of chronic diazepam treatment on hypoxia-induced alterations in functional activity of guinea pig myocardium

A. Ujfalusi, Á Cseppento, K. Antal, J. Szabó, P. Kovács, A. J. Szentmiklósi

Research output: Contribution to journalArticle

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Abstract

The concentration-related sensitization of guinea pig left atrium to adenosine in the presence of diazepam is well established. It was found in our experiments that the cardiodepressive action of hypoxia is significantly enhanced by diazepam in the left atrial myocardium. In atrial preparations obtained from guinea pigs treated with diazepam for 10 days, the hypoxia-induced depression of myocardial contractility was not altered. These results indicate that diazepam-treatment does not impaire the hypoxic tolerance of myocardium.

Original languageEnglish
Pages (from-to)345-346
Number of pages2
JournalActa Physiologica Hungarica
Volume84
Issue number3
Publication statusPublished - 1996

Fingerprint

Diazepam
Myocardium
Guinea Pigs
Heart Atria
Adenosine
Hypoxia

Keywords

  • Adenosine
  • Diazepam
  • Hypoxia
  • Myocardium
  • Reoxygenation

ASJC Scopus subject areas

  • Physiology

Cite this

The effect of chronic diazepam treatment on hypoxia-induced alterations in functional activity of guinea pig myocardium. / Ujfalusi, A.; Cseppento, Á; Antal, K.; Szabó, J.; Kovács, P.; Szentmiklósi, A. J.

In: Acta Physiologica Hungarica, Vol. 84, No. 3, 1996, p. 345-346.

Research output: Contribution to journalArticle

Ujfalusi, A, Cseppento, Á, Antal, K, Szabó, J, Kovács, P & Szentmiklósi, AJ 1996, 'The effect of chronic diazepam treatment on hypoxia-induced alterations in functional activity of guinea pig myocardium', Acta Physiologica Hungarica, vol. 84, no. 3, pp. 345-346.
Ujfalusi, A. ; Cseppento, Á ; Antal, K. ; Szabó, J. ; Kovács, P. ; Szentmiklósi, A. J. / The effect of chronic diazepam treatment on hypoxia-induced alterations in functional activity of guinea pig myocardium. In: Acta Physiologica Hungarica. 1996 ; Vol. 84, No. 3. pp. 345-346.
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