The effect of chronic alcohol ingestion on the contractile proteins of the rat heart.

I. Édes, O. Takács, M. Csanády, F. Guba

Research output: Contribution to journalArticle

Abstract

With increasing duration of alcohol consumption the amounts of total myofibrillar proteins in CFY rats decreased slightly, but significantly (from 63.3 +/- 5.7 mg X g wet muscle weight to 54.9 +/- 5.9 mg X g-1 after 12 weeks on alcohol). Similar slight changes could be observed in the case of sarcoplasmic proteins. No significant changes were observed in the composition of the myofibrillar proteins. The densitiometrically calculated percentage ratios of myosin/actin, myosin light chains (LC1/LC2) and troponin components remained the same in the alcoholic animals. The same distribution of native myosin isoenzymes was found in the ventricles of the alcoholic animals as in the controls. We found no electrophoretically detectable evidence that a change in the composition of the myofibrillar proteins is responsible for the decreased contractility of the rat heart following chronic alcohol ingestion.

Original languageEnglish
Pages (from-to)205-214
Number of pages10
JournalActa Biochimica et Biophysica Hungarica
Volume21
Issue number3
Publication statusPublished - 1986

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Contractile Proteins
Rats
Eating
Alcohols
Myosins
Animals
Proteins
Myocardial Contraction
Myosin Light Chains
Troponin
Chemical analysis
Alcohol Drinking
Isoenzymes
Muscle
Actins
Weights and Measures
Muscles

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics

Cite this

The effect of chronic alcohol ingestion on the contractile proteins of the rat heart. / Édes, I.; Takács, O.; Csanády, M.; Guba, F.

In: Acta Biochimica et Biophysica Hungarica, Vol. 21, No. 3, 1986, p. 205-214.

Research output: Contribution to journalArticle

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