The effect of carotid stenting on rheological parameters, free radical production and platelet aggregation

L. Szapáry, E. Bagoly, F. Kover, G. Fehér, E. Pozsgai, K. Koltai, K. Hanto, S. Komoly, T. Dóczi, K. Tóth

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction: Carotid artery stenting has become a possible treatment of significant carotid stenosis. The risk of stent occlusion and restenosis might be increased by abnormal rheological conditions amplified platelet aggregation and free radical production during the operation. Aims: The aim of our study was to assess the changes in hemorheological parameters, platelet aggregation, and catalase activity after endovascular treatment of carotid stenosis. Methods: 18 patients (11 men. ages 68 ± 9 years and 7 women, ages 62 ± 8 years) suffering from significant carotid stenosis and treated with carotid endovascular intervention were examined. Alteration in hemorheological parameters as well as epinephrine-, ADP-, and collagen-induced platelet aggregation were evaluated. Antioxidant reserve was characterized by the determination of catalase activity. The measurements were carried out directly before and after the procedure and 1, 2, 5 days and 1 month following the intervention. Preceding the operation the patients were administered a maximum dose (300 mg) of Clopidogrel. Results: Hematocrit, plasma fibrinogen concentration (PFC) and whole blood-, and plasma viscosity values (WBV and PV) significantly decreased immediately after stenting (p <0.001). By the fifth day following the intervention the PFC, WBV, PV, red blood cell (RBC) aggregation and ADP-induced platelet aggregation significantly increased (p <0.0001) compared to values measured postprocedurally. At 1 month follow-up these parameters. except whole blood viscosity, decreased significantly compared to measurements made on the 5th day. On the other hand, catalase activity showed significant elevation by the end of the first month. Conclusion: Hemorheological parameters and platelet aggregation showed specific changes following carotid stenting. Abnormal changes of the rheological conditions and increasing platelet activation are the most pronounced in the first week following stenting, which may lead to early stent occlusion. Oxidative stress production returned to baseline levels only by the end of the first month.

Original languageEnglish
Pages (from-to)209-217
Number of pages9
JournalClinical Hemorheology and Microcirculation
Volume43
Issue number3
DOIs
Publication statusPublished - 2009

Fingerprint

Platelet Aggregation
Free Radicals
Carotid Stenosis
Catalase
Blood Viscosity
clopidogrel
Adenosine Diphosphate
Fibrinogen
Stents
Cell Aggregation
Platelet Activation
Hematocrit
Carotid Arteries
Epinephrine
Oxidative Stress
Collagen
Antioxidants
Erythrocytes
Therapeutics

Keywords

  • Carotid stenting
  • Oxidative stress
  • Platelet aggregation
  • Rheology

ASJC Scopus subject areas

  • Hematology
  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

The effect of carotid stenting on rheological parameters, free radical production and platelet aggregation. / Szapáry, L.; Bagoly, E.; Kover, F.; Fehér, G.; Pozsgai, E.; Koltai, K.; Hanto, K.; Komoly, S.; Dóczi, T.; Tóth, K.

In: Clinical Hemorheology and Microcirculation, Vol. 43, No. 3, 2009, p. 209-217.

Research output: Contribution to journalArticle

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abstract = "Introduction: Carotid artery stenting has become a possible treatment of significant carotid stenosis. The risk of stent occlusion and restenosis might be increased by abnormal rheological conditions amplified platelet aggregation and free radical production during the operation. Aims: The aim of our study was to assess the changes in hemorheological parameters, platelet aggregation, and catalase activity after endovascular treatment of carotid stenosis. Methods: 18 patients (11 men. ages 68 ± 9 years and 7 women, ages 62 ± 8 years) suffering from significant carotid stenosis and treated with carotid endovascular intervention were examined. Alteration in hemorheological parameters as well as epinephrine-, ADP-, and collagen-induced platelet aggregation were evaluated. Antioxidant reserve was characterized by the determination of catalase activity. The measurements were carried out directly before and after the procedure and 1, 2, 5 days and 1 month following the intervention. Preceding the operation the patients were administered a maximum dose (300 mg) of Clopidogrel. Results: Hematocrit, plasma fibrinogen concentration (PFC) and whole blood-, and plasma viscosity values (WBV and PV) significantly decreased immediately after stenting (p <0.001). By the fifth day following the intervention the PFC, WBV, PV, red blood cell (RBC) aggregation and ADP-induced platelet aggregation significantly increased (p <0.0001) compared to values measured postprocedurally. At 1 month follow-up these parameters. except whole blood viscosity, decreased significantly compared to measurements made on the 5th day. On the other hand, catalase activity showed significant elevation by the end of the first month. Conclusion: Hemorheological parameters and platelet aggregation showed specific changes following carotid stenting. Abnormal changes of the rheological conditions and increasing platelet activation are the most pronounced in the first week following stenting, which may lead to early stent occlusion. Oxidative stress production returned to baseline levels only by the end of the first month.",
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AU - Szapáry, L.

AU - Bagoly, E.

AU - Kover, F.

AU - Fehér, G.

AU - Pozsgai, E.

AU - Koltai, K.

AU - Hanto, K.

AU - Komoly, S.

AU - Dóczi, T.

AU - Tóth, K.

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N2 - Introduction: Carotid artery stenting has become a possible treatment of significant carotid stenosis. The risk of stent occlusion and restenosis might be increased by abnormal rheological conditions amplified platelet aggregation and free radical production during the operation. Aims: The aim of our study was to assess the changes in hemorheological parameters, platelet aggregation, and catalase activity after endovascular treatment of carotid stenosis. Methods: 18 patients (11 men. ages 68 ± 9 years and 7 women, ages 62 ± 8 years) suffering from significant carotid stenosis and treated with carotid endovascular intervention were examined. Alteration in hemorheological parameters as well as epinephrine-, ADP-, and collagen-induced platelet aggregation were evaluated. Antioxidant reserve was characterized by the determination of catalase activity. The measurements were carried out directly before and after the procedure and 1, 2, 5 days and 1 month following the intervention. Preceding the operation the patients were administered a maximum dose (300 mg) of Clopidogrel. Results: Hematocrit, plasma fibrinogen concentration (PFC) and whole blood-, and plasma viscosity values (WBV and PV) significantly decreased immediately after stenting (p <0.001). By the fifth day following the intervention the PFC, WBV, PV, red blood cell (RBC) aggregation and ADP-induced platelet aggregation significantly increased (p <0.0001) compared to values measured postprocedurally. At 1 month follow-up these parameters. except whole blood viscosity, decreased significantly compared to measurements made on the 5th day. On the other hand, catalase activity showed significant elevation by the end of the first month. Conclusion: Hemorheological parameters and platelet aggregation showed specific changes following carotid stenting. Abnormal changes of the rheological conditions and increasing platelet activation are the most pronounced in the first week following stenting, which may lead to early stent occlusion. Oxidative stress production returned to baseline levels only by the end of the first month.

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KW - Platelet aggregation

KW - Rheology

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